提阿佐利丁二是部分有效的苦味抑制剂
Ha Nguyen1, Cailu Lin1, Ivona Sasimovich1
1Monell Chemical Senses Center, Philadelphia, Pennsylvania.
Clinical therapeutics
|March 10, 2024
概括
thiazolidinediones (TZDs) 部分阻断了苦药的味道,但效果因药物,个体和人群而异. 需要进一步的研究来优化这些苦药阻塞剂,以便更好地遵守药物.
科学领域:
- 药理学 药理学是指药理学的学科.
- 感官科学 感官科学
- 药物开发 药物开发
背景情况:
- 药物的苦味对患者的遵守构成了重大障碍,特别是儿童和老年人使用的必需药物.
- 开发有效的苦药阻断剂对于改善治疗结果和公共健康至关重要.
研究的目的:
- 评估一种新型苦味阻断剂类型的疗效,即 thiazolidinediones (TZDs),用于掩盖特定药物的苦味.
- 为了比较罗西格利塔 (ROSI) 和更简单的TZD与已知的甜味剂对照剂的苦味阻断作用.
主要方法:
- 两个 thiazolidinediones (TZDs) 和一个阳性对照 (neohesperidin dihydrochalcone,NHDC) 被测试.
- 味道测试是通过使用苦药的两个小组 (一般和遗传信息) 进行的:tenofovir alafenamide fumarate (TAF) 和praziquantel (PRAZ).
- 参与者在100分视觉模拟尺度上对苦味强度进行了评分.
主要成果:
- 观察到TAF和PRAZ的感知苦味在人与人之间存在显著的变化.
- 与单独相比,TAF和PRAZ在与NHDC相结合时被评为不那么苦.
- 罗西格利塔 (ROSI) 部分抑制了苦味,在两个味觉板之间对TAF和PRAZ产生了不同的影响.
结论:
- thiazolidinediones (TZDs) 作为苦药阻断剂的部分有效性被证明,其有效性在不同药物,个体和人群之间有所不同.
- 需要对TZD苦药阻断剂进行进一步的研究,重点关注多样化的人口和更广泛的药物范围.
- 有效的苦味受体阻塞剂的开发有望提高药物坚持.
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