亚洲冲是一种潜在的防护因素,对COVID-19:一个基于网络的回顾性调查在日本
Satoshi Takashima1,2, Mikiko Tokiya1, Katsura Izui3
1Department of Social and Environmental Medicine, Saga University.
由酒精冲洗反应表示的脱酶2 rs671变体,可能会防止COVID-19. 具有这种遗传特征的个人经历了较低的感染和住院率,这表明对2019年冠状病毒疾病的保护作用.
科学领域:
- 遗传学和人类生物学
- 传染病流行病学 传染病流行病学
- 药物基因组学 药物基因组学
背景情况:
- 新型冠状病毒疾病2019 (COVID-19) 在全球范围内传播,东亚的死亡率较低.
- 在东亚人中普遍存在的脱酶2 (ALDH2) rs671遗传变异被假设能提供对感染的保护.
研究的目的:
- 通过酒精冲洗反应识别的ALDH2 rs671变种与COVID-19的发病率和严重程度之间的联系进行调查.
- 为了确定rs671变种是否对COVID-19感染和住院治疗具有保护作用.
主要方法:
- 使用基于网络的调查来收集有关COVID-19发病率和酒精冲洗反应的数据的回顾性研究.
- 分析了807个有效的答案,根据酒精消费情况将参与者分为冲洗者或非冲洗者.
- 统计分析包括斯皮尔曼等级相关性,生存分析和考克斯比例危险模型.
主要成果:
- 与非冲洗者 (n=362) 相比,冲洗者 (n=445) 显示出较晚COVID-19发病的趋势.
- 冲洗者在COVID-19住院率 (0.5%对2.5%) 和整体发病率上显著降低.
- 考克斯模型分析表明,在冲洗者与非冲洗者中,COVID-19发病率的危险比为0.21,经过对共变量进行调整.
结论:
- 酒精冲洗现象是ALDH2 rs671变种的标志物,与COVID-19发病率和住院治疗风险降低有关.
- rs671变种似乎是对COVID-19的保护因素,有助于了解东亚人口的独特遗传多样性.
- 研究结果为感染控制策略提供了洞察力,并突出了遗传因素在疾病易感性中的作用.
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