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化-脂质体的多克索鲁比诱导的淋巴体血栓微血管病变

Shingo Yokoyama¹, Kota Kakeshita¹, Teruhiko Imamura¹

¹The Second Department of Internal Medicine, University of Toyama, Japan.

Internal medicine (Tokyo, Japan)

|March 10, 2024

概括

化脂质体多克索鲁比 (PLD) 治疗可能会导致血栓性微血管病变,这是一个罕见的疾病. 这一案例凸显了在长期PLD治疗期间需要考虑这种诊断在患有不明原因高血压和脏问题的患者.

科学领域:

在瘤学瘤学.
药理学药理学是指药理学的学科.
腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

化脂体 doxorubicin (PLD) 是一种使用脂体封装 doxorubicin 的抗瘤剂.
由于其降低了心脏毒性概况,PLD在临床上越来越多地使用.

研究的目的:

报告一个罕见的PLD相关的血栓性微血管病变 (PLD-TMA) 病例.
强调在长期PLD单一治疗期间考虑PLD-TMA在无法解释的高血压和功能障碍患者中的重要性.

主要方法:

对一个患者进行了详细的病理生理评估,该患者在延长PLD治疗复发性恶性瘤后发展出血栓性微血管病变.
分析了临床表现,实验室发现和诊断评估.

主要成果:

患者出现了与PLD相关的血栓性微血管病变.
在这种情况下,无法解释的高血压和功能障碍是关键指标.

结论:

血栓式微血管病是长期化脂质体多克索鲁比单疗的潜在并发症,尽管很少见.
在延长PLD治疗期间,临床医生应在患有不明原因的高血压和功能障碍的患者中保持对PLD-TMA的高度怀疑指数.

关键词:

药物诱导的损伤导致损伤.脂质体组是什么? 脂质体组是什么?卵巢癌是发生在卵巢的癌症.聚乙烯糖醇 (PEG) 是一种蛋白质尿症是一种蛋白质尿症.

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