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在甲状腺前孕期妇女中评估异常甲状腺蛋白的进展:基于人口的研究
Rili Gao1, Xinyi Lyu2,3,4, Ying Yang2,3,4
1Department of Endocrinology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Thyroid research
|March 11, 2024
概括
基线低和高的甲状腺激素水平都会增加甲状腺功能异常的风险. 最佳的孕前甲状腺激素水平对于降低风险和确保健康怀孕至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 甲状腺功能 甲状腺功能
背景情况:
- 异常预先怀孕 甲状腺增生素与生育能力和怀孕并发症有关.
- 有限的数据存在于怀孕前的甲状腺女性的自然甲状腺蛋白变化.
研究的目的:
- 评估在生育年龄的甲状腺功能良好妇女中,甲状腺激素水平向异常水平的进展.
- 为了确定最佳的孕前甲状腺激素范围,以尽量减少甲状腺异常进展.
主要方法:
- 使用国家免费怀孕前检查项目 (2010-2020) 的数据进行了回顾性队列研究.
- 包括186,095名带有正常初始甲状腺激素和1.5-3.0年随访的甲状腺功能良好的妇女.
- 分析了使用统计建模的甲状腺激素变化和相关风险.
主要成果:
- 4.57%的女性出现了异常的甲状腺增生蛋白 (非正常或超正常).
- 基线较低和较高的甲状腺激素水平与分别低于正常和超正常水平的风险增加相关.
- 观察到U形和J形的剂量反应关联,用于非正常和超正常的甲状腺激素风险.
结论:
- 基线低和高的甲状腺激素水平都显著增加了发展异常甲状腺激素的风险.
- 最佳的孕前甲状腺激素水平可能在1.43-1.93 mIU/L (或0.59-1.36 MoM) 之间,以减少进展到异常水平.
- 这些发现支持改善孕前辅导和甲状腺功能监测.
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