在灵长类大脑中,分布式功能模式的局部编排支持意识丧失和恢复
Andrea I Luppi1,2, Lynn Uhrig3,4, Jordy Tasserie3,5
1Division of Anaesthesia and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. al857@cam.ac.uk.
Nature communications
|March 11, 2024
概括
意识依赖于分布式的大脑活动模式. 特定的乳头刺激扭转了麻醉引起的大脑组织的约束,恢复了兴奋和意识.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 系统神经科学 系统神经科学
背景情况:
- 了解意识的神经基础是神经科学的一个基本挑战.
- 人们认为意识取决于复杂的,分布式的脑活动模式.
研究的目的:
- 为了研究意识丧失如何影响大规模大脑组织.
- 确定特定的胸膜核在意识编排中的作用.
主要方法:
- 结合焦点深度大脑刺激与全脑功能磁共振成像 (fMRI) 在非人类灵长类动物.
- 给药麻醉剂 (propofol,sevoflurane,ketamine) 诱导意识丧失,并刺激中央和腹侧丘脑,以评估对大脑活动和兴奋的影响.
主要成果:
- 麻醉导致大脑结构在各个尺度上增加了大脑活动的约束,崩了层次性的皮质组织.
- 中部丘脑的电刺激扭转了这些影响,恢复了兴奋和意识.
- 刺激腹侧丘脑并没有产生类似的效果,这表明特异性.
结论:
- 意识的分布式大脑签名由特定的脑核一致地观察和编排.
- 中部丘脑通过其对大脑组织的影响,在维持意识方面发挥着至关重要的作用.
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