短期减少饮食中的谷蛋白可以改善与代谢功能障碍相关的脂肪性肝病:一项随机对照的概念验证研究
Angelo Armandi1,2, Helena Bespaljko2, Alexander Mang2
1Department of Medical Sciences, Division of Gastroenterology and Hepatology, University of Turin, Turin, Italy.
Alimentary pharmacology & therapeutics
|March 11, 2024
概括
短期的,没有氨酸素抑制剂 (ATI) 的饮食显著改善了MASLD患者的肝脂肪,BMI和胰岛素抵抗. 这种饮食方法也提高了患者报告的结果,表明了有前途的治疗策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 免疫学 免疫学 免疫学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 管理主要涉及生活方式的改变.
- 在MASLD模型中,营养小麦氨酸素抑制剂 (ATI) 激活通关类受体4,促进炎症,胰岛素抵抗和肝纤维化.
研究的目的:
- 评估无ATI饮食对肝脏和活检证明的MASLD患者的代谢参数的疗效.
- 评估无ATI饮食对MASLD患者报告结果的影响.
主要方法:
- 一项为期6周的随机对照试验,将无ATI饮食与均衡饮食进行比较.
- 对肝脂肪的控制减弱参数 (CAP),体重指数 (BMI) 和对胰岛素抵抗的HOMA-IR的评估.
- 利用CLDQ-NASH问卷调查患者报告的结果.
主要成果:
- 与基线和对照组相比,无ATI饮食组的BMI,CAP和HOMA-IR显著减少.
- 在无ATI饮食组中观察到CAP的显著改善 (平均差异为30.5dB/m).
- 无ATI饮食导致患者报告结果的显著改善,包括总的CLDQ-NASH得分.
结论:
- 短期不含ATI的饮食在MASLD患者中显著改善了肝硬化,代谢健康和患者报告的结果.
- 没有ATI的饮食被很好地容忍,这表明它作为治疗干预的潜力.
- 需要进一步进行更大规模的研究来证实这些初步发现.
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