用于控制药物释放的聚合物pH响应水凝的制备,体外表征和评估
Tahir Mahmood1, Rai M Sarfraz1, Asif Mahmood2
1College of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.
ACS omega
|March 11, 2024
概括
研究人员开发了PEG-g-poly(MAA) 共聚合物纳米凝,以提高溶解度,并实现像奥尔梅沙坦这样的疏水药物的持续释放. 这些新型纳米凝显示出显著的可溶性增强和生物相容性,为先进的药物输送系统提供了潜力.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
背景情况:
- 疏水性药物由于溶解性差,存在重大制剂挑战.
- 提高药物溶解度对于有效的治疗输送和生物可用性至关重要.
- 需要智能药物输送系统来控制和向释放活性药物成分.
研究的目的:
- 制备PEG-g-poly(MAA) 共聚合物纳米凝,以提高溶解度和持续释放疏水药物.
- 研究开发的纳米凝的物理化学特性,稳定性和药物载荷能力.
- 评估这些纳米凝作为生物相容药物输送平台的潜力.
主要方法:
- 自由基聚合被用来合成PEG-g-poly ((MAA) 共聚合物纳米凝.
- 准备和描述了九种不同的配方.
- 物理化学评估包括FTIR,TGA,DSC,SEM和PXRD. 这些测试包括:
- 进行了溶解性,溶解性,毒性和稳定性研究.
主要成果:
- FTIR证实了奥尔梅沙坦封装的成功.
- TGA和DSC验证了纳米凝的热稳定性.
- SEM揭示了多孔的纳米凝结构,PXRD表明了无形的性质.
- 通过配方NGP3.3,可溶性在pH 1.2时增加了12.3倍,在pH 6.8时增加了13.29倍.
- 在pH值6.8与pH值1.2相比,观察到显著的胀.
结论:
- 开发的PEG-g-poly(MAA) 纳米凝系统有效地提高了olmesartan的溶解性.
- 纳米凝具有持续药物释放的理想特性,无毒且生物相容.
- 这种智能纳米凝平台具有相当大的潜力,可以提供药物,蛋白质和热敏分子.
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