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在长期COVID时代的创伤性脑损伤

Denes V Agoston¹

¹Department of Anatomy, Physiology, and Genetics, School of Medicine, Uniformed Services University, Bethesda, Maryland, USA.

Neurotrauma reports

|March 11, 2024

概括

了解长期COVID/PASC和创伤性脑损伤 (TBI) 需要采用整体方法. 检查生物背景和生物标志物可以改善TBI患者的治疗.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
传染性疾病传染性疾病

背景情况:

生物背景因素 (年龄,性别,并发症,药物) 显著影响创伤性脑损伤 (TBI) 后的结果.
关于2019年冠状病毒病 (COVID-19) 和其慢性形式长期COVID (急性后续SARS-CoV-2感染/PASC) 的广泛研究,提供了关于疾病整体性和器官系统相互连接的见解.
一个全面的方法对于理解TBI引起的条件至关重要.

研究的目的:

审查关于长期COVID/PASC及其病理的当前知识.
概述由TBI (内分类型) 引起的病理生物学变化.
探索长期COVID/PASC和TBI病理生物学的交集,并为TBI患者提出改善的临床管理策略.

主要方法:

关于长期COVID/PASC和TBI研究的文献综述.
在TBI中分析病理生物学机制和内分类型.
讨论长期COVID/PASC和TBI之间的相互作用.

主要成果:

长期COVID/PASC研究强调了生物背景对疾病轨迹和结果的重要性.
创伤诱导特定的病理生物学变化 (内分类型).
长期COVID/PASC和TBI的交集表明共享或相互作用的病理生物学.

结论:

考虑个体的生物学背景因素对于有效的TBI管理至关重要.
结合机械分子生物标志物可以增强TBI患者的临床决策.
一种整体的系统生物学方法对于推进TBI护理至关重要.

关键词:

这是生物储备.这种疾病是共患的.创伤性脑损伤是一种创伤性脑损伤

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