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XRCC1和hOGG1多态和子宫内膜癌:一个元分析

Shengke He¹, Xiujuan Zhao², Ruifang Mu²

¹Department of Pathology, Danzhou People's Hospital, Nada Town, Danzhou, Hainan, 571799, China.

Open medicine (Warsaw, Poland)

|March 11, 2024

概括

修复DNA基因变异,特别是XRCC1-Arg399Gln和hOGG1-Ser326Cys,与子宫内膜癌 (EC) 风险增加有关,特别是在高加索女性中. 对更广泛的种族群体需要进一步的研究.

科学领域:

遗传学是一个遗传学.
在瘤学瘤学.
分子流行病学分子流行病学

背景情况:

子宫内膜癌 (EC) 的病因是多因素的.
包括XRCC1-Arg399Gln和hOGG1-Ser326Cys在内的DNA修复基因多态性涉及,但它们与EC风险的直接关联尚不清楚.

研究的目的:

系统地审查和元分析XRCC1-Arg399Gln和hOGG1-Ser326Cys多态性和子宫内膜癌风险之间的关联.

主要方法:

按照PRISMA指南进行了系统审查和元分析.
数据从四个数据库的基于人口的病例控制研究中提取.
使用纽卡斯尔-太华尺度评估研究质量,并计算了95%置信区间 (CI) 的聚合几率比率 (OR),包括按种族分类的子组分析.

主要成果:

七项研究符合纳入标准.
无论是XRCC1-Arg399Gln还是hOGG1-Ser326Cys的多态都与EC的风险增加有显著的关联.
这种关联在高加索人群中尤为明显,对于每个多重形态的支配性,同性和等位基因模型报告了特定的OR.

结论:

XRCC1-Arg399Gln和hOGG1-Ser326Cys多态可能导致子宫内膜癌易感性增加,特别是在高加索女性中.
这些发现凸显了DNA修复机制在EC发展中的潜在作用.
需要进一步的研究来验证这些结果在不同的种族群体和探索其他相关的DNA修复基因多态.

关键词:

XRCC1-Arg399Glnnn 在线播放宫内膜癌 (Endometrial Carcinoma) 是一个体内膜癌.遗传易感性是一种基因易感性.hOGG1-Ser326Cys 的使用情况.进行元分析.多形态主义的多态主义.

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