多omics分析揭示了来自不同生长年龄的三个主要Dendrobium物种对药物成分的反应
Yingdan Yuan1, Jiajia Zuo1, Xin Wan2,3
1College of Horticulture and Landscape Architecture, Yangzhou University, Yangzhou, China.
Frontiers in plant science
|March 11, 2024
概括
这项研究揭示了Dendrobium物种和年龄如何影响药用黄酸盐含量. 微生物组中的活性菌与植物随着年龄的增长而增加的黄化合物合成有关.
科学领域:
- 植物科学 植物科学
- 基因组学就是基因组学.
- 代谢学 代谢学 代谢学
- 微生物组研究 微生物组研究
背景情况:
- 来自亚洲的Dendrobium草药具有药用和装饰价值.
- 茎是Dendrobium物种的主要药用部分.
- 了解影响药物化合物含量的因素至关重要.
研究的目的:
- 为了调查Dendrobium物种和年龄对药物成分含量的影响.
- 分析Dendrobium中转录组,代谢组和微生物组之间的相互作用.
主要方法:
- 收集的茎来自1至4岁的D. officinale,D. moniliforme和D. huoshanense. 这三种植物.
- 进行了全面的多omics测序:转录组,代谢组和微生物组.
- 分析了差异表达基因 (DEG) 和差异积累代谢物 (DAM),绘制了黄胺路径.
主要成果:
- 在12个比较组中确定了10426个DEG和644个DAM.
- 转录组和代谢组数据显示,在三个Dendrobium物种中,黄类积累增加.
- 作为Dendrobium的老化,Actinobacteria显示出与黄类合成的积极关联.
结论:
- 丹德罗体中的黄类积累受物种和年龄的影响.
- 植物的转录基因组和代谢基因组是生产黄酸的关键参与者.
- 微生物组,特别是动氨酸菌,与宿主代谢相互作用以合成黄酸盐,特别是在老植物中.
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