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甲状腺自身免疫与HLA-DRB1和HLA-DQB1在非细分性白风中的多态:一个横截面研究
Abdellatif Bouayad1, Laila Benzekri2
1Faculty of Medicine and Pharmacy, Mohammed First University Oujda, Morocco.
American journal of translational research
|March 11, 2024
概括
人类白细胞抗原 (HLA) 基因变异,特别是HLA-DQB1多态,与非细分性白风 (NSV) 患者的甲状腺自身免疫 (TAI) 有关. 这些遗传因素有助于NSV患者的TAI易感性.
科学领域:
- 免疫遗传学 免疫遗传学
- 皮肤病学 皮肤病学
- 内分泌学 在内分泌学.
背景情况:
- 非细分性白风 (NSV) 经常与甲状腺自身免疫 (TAI) 相关.
- 这种关联背后的确切免疫病原机制需要进一步研究.
- 了解影响NSV患者TAI的遗传因素至关重要.
研究的目的:
- 为了确定TAI在摩洛哥NSV患者的频率.
- 分析人类白细胞抗原 (HLA) -DRB1和-DQB1位点中的遗传多态性,与NSV患者的TAI敏感性相关.
主要方法:
- 一项涉及97名摩洛哥NSV患者的横截面研究.
- 通过测量抗甲状腺过氧化酶 (TPOAb) 和抗甲状腺球蛋白 (TGAb) 抗体来查TAI.
- 使用单一特异性原料聚合酶链反应 (PCR-SSP) 方法进行HLA-DRB1和-DQB1基因型鉴定.
主要成果:
- 在NSV患者中,TAI被诊断为20.6%.
- 在TAI的NSV患者中观察到DQB1*05等位基因 (OR=5.04) 的频率显著更高.
- 在NSV患者中,DQB1*05/DQB1*06基因型赋予了对TAI的敏感性 (OR=25.33).
- 患有TAI的NSV患者的早期白风显示DQB1*05等位基因和DQB1*05/DQB1*06基因型的高频率.
- 临床甲状腺疾病在6.2%的NSV患者中被观察到.
结论:
- HLA-DQ多态似乎影响了NSV.个体TAI的风险.
- 虽然HLA关联是显著的,但它们并不能完全解释NSV和TAI的同时发生.
- 需要进一步的研究来阐明完整的免疫病原性机制.
关键词:
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