心率碎片化,循环血压和冠状动脉化:一个基于人口的研究
Yuichi Sawayama1, Yuichiro Yano2, Takashi Hisamatsu2,3
1Department of Cardiovascular Medicine, Shiga University of Medical Science, Otsu, Japan.
JACC. Asia
|March 11, 2024
概括
睡眠期间心率碎片化 (HRF) 和静脉血压 (SBP) 的增加与男性的冠状动脉结石化 (CAC) 有关. 这表明HRF可能是心血管风险的早期指标.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 公共卫生 公共卫生
背景情况:
- 超快速心率变化模式,如心率碎片化 (HRF),与冠状动脉化 (CAC) 在一般人群中关系不明.
- 亚临床动脉样硬化,由CAC表示,是心血管事件的重要危险因素.
研究的目的:
- 在一般人群中调查HRF和CAC之间的关联.
- 要确定这种关联是否独立于缩血压 (SBP) 水平.
主要方法:
- 利用了来自西加亚临床动脉样硬化 (SESSA) 流行病学研究的数据.
- 评估了24小时门诊血压监测,用于清醒和睡眠的SBP.
- 使用24小时霍尔特监测的百分比拐点 (PIP) 来量化HRF.
- 使用计算机断层扫描的Agatston得分来测量CAC.
- 使用多变量逻辑回归来分析关联.
主要成果:
- 这项研究包括508名参与者 (平均年龄66.5岁),其中64%患有CAC.
- 较高的清醒时SBP (OR 1.40,95% CI: 1.11-1.77) 和睡眠时SBP (OR 1.28,95% CI: 1.02-1.60) 与普遍的CAC相关.
- 较高的清醒PIP (OR 1.23,95%CI:0.99-1.54) 和睡眠PIP (OR 1.31,95%CI:1.05-1.62) 也与CAC有关.
- 在PIP和门诊SBP之间没有发现关于CAC存在的显著相互作用.
结论:
- 睡眠期间HRF和SBP水平升高与一般男性人口中CAC的存在独立相关.
- HRF,特别是在睡眠期间,可能作为亚临床冠状动脉样硬化症的新生物标志物.
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