在COH中hCG管理之前雌激素的下降对没有OC预治疗的患者的试管婴儿结果产生负面影响
Yinci Zhu1,2, Zhong Zheng1,2, Bihong Fan1,2
1Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200135, People's Republic of China.
在人类胆管激素 (hCG) 触发前雌激醇 (E2) 水平的下降会对体外受精 (IVF) 结果产生负面影响. 口服避孕药的预治疗可以减轻这些对怀孕和活产率的不良影响.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精过程中受精.
- 临床胚胎学 临床胚胎学
背景情况:
- 血清雌激醇 (E2) 水平和超声波对于指导受控的卵巢过度刺激 (COH) 是至关重要的.
- 在COH期间E2水平的降低,特别是在人类胆管性腺激素 (hCG) 服药之前,可能会发生在一些患者身上.
- 这种E2下降的影响和口服避孕药 (OC) 前期治疗对试管婴儿结果的影响需要进一步调查.
研究的目的:
- 研究hCG触发前血清E2水平降低对试管婴儿和临床结果的影响.
- 评估口服避孕药 (OC) 预治疗对缓解COH期间E2下降的不良影响的作用.
主要方法:
- 从2013年到2019年进行了一项回顾性研究.
- 333名患者的E2在hCG之前下降,与333名控制组的E2持续增加进行了比较.
- 患者被分为OC和非OC预治疗子组,以比较试管婴儿和临床结果.
主要成果:
- 在E2下降组显示显着较少的主导卵泡和正常受精的卵巢.
- 在E2下降组中,活产率显著降低,这表明E2下降和临床结果之间存在联系.
- 在没有OC预治疗的患者中,E2下降组与对照组相比,怀孕和活产率较低. 在接受OC预治疗的患者中没有观察到显著差异.
结论:
- 在hCG触发之前雌激素的下降会对IVF和临床结果产生不利影响,特别是未经OCs预治疗的患者的受精和活产率.
- 口服避孕药预治疗可能起到保护作用,在E2下降的情况下可能使结果正常化.
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