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相关概念视频

Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
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The Extracellular Matrix01:42

The Extracellular Matrix

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Overview
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Vesicular Tubular Clusters01:45

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After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
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Extracellular Matrix01:26

Extracellular Matrix

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Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
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Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
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相关实验视频

Updated: Jul 1, 2025

2D and 3D Matrices to Study Linear Invadosome Formation and Activity
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细胞外囊泡-矩阵相互作用.

Koushik Debnath1,2, Kevin Las Heras1,2,3,4, Ambar Rivera1,2,5

  • 1Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

Nature reviews. Materials
|March 11, 2024
PubMed
概括
此摘要是机器生成的。

细胞外囊泡 (EVs) 与细胞外基质相互作用,影响组织功能. 了解这些相互作用使得工程生物材料能够精确地提供治疗性EV.

关键词:
生物材料是一种生物材料.细胞外矩阵是细胞外矩阵.细胞外囊泡细胞外囊泡纳米级生物物理学的纳米级生物物理学.纳米技术是纳米技术.

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相关实验视频

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Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
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科学领域:

  • 生物材料科学 生物材料科学
  • 细胞生物学 细胞生物学
  • 组织工程是组织工程.

背景情况:

  • 细胞外基质 (ECM) 通过各种信号调节细胞功能和组织特性.
  • 目前的合成生物材料往往将基于聚合物的线索与细胞分泌的因素分开.
  • 细胞释放纳米级的细胞外囊泡 (EVs),与ECM相互作用.

研究的目的:

  • 审查细胞外囊泡-矩阵相互作用.
  • 探索细胞如何控制EV生物发生,以应对ECM.
  • 讨论决定EV分泌后命运的因素及其治疗潜力.

主要方法:

  • 关于细胞外囊泡-矩阵相互作用的文献综述.
  • 对控制EV生物发生的细胞反机制的分析.
  • 检查影响EV局部化的生物分子和生物物理因素.

主要成果:

  • 电动车是ECM的组成部分,调解细胞矩阵通信.
  • 受ECM影响的细胞过程调节了EV的产生和释放.
  • EV的命运 (保留,运输,吸收) 是由矩阵内的复杂相互作用决定的.

结论:

  • 了解EV-矩阵相互作用对于生物材料设计至关重要.
  • 工程生物材料可以控制治疗应用的EV释放和保留.
  • 对EV局部的精确控制可以在宿主组织中引起所需的生物和治疗结果.