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基因剂量依赖性减少Fshr表达改善了阿尔茨海默病小鼠的空间记忆缺陷

Tal Frolinger1, Funda Korkmaz1, Steven Sims1

  • 1Icahn School of Medicine at Mount Sinai.

Research square
|March 11, 2024
PubMed
概括

抑制卵泡刺激激素 (FSH) 信号传递,在阿尔茨海默氏病 (AD) 的小鼠模型中保护了对认知衰退和记忆丧失的保护. 对FSH受体 (Fshr) 的遗传衰竭防止了空间和识别记忆缺陷,这表明AD预防的治疗目标.

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