集体电转动中的空间异质性:连续性建模和用于最佳控制的应用
Simon F Martina-Perez1, Isaac B Breinyn2, Daniel J Cohen3
1Mathematical Institute, University of Oxd, Oxford, United Kingdom.
bioRxiv : the preprint server for biology
|March 11, 2024
概括
集体电转动涉及细胞在电场中移动. 一个新的模型解释了上皮层的速度变化,使得可以控制集体细胞迁移模式.
科学领域:
- 细胞生物物理学 细胞生物物理学
- 发展生物学 发展生物学
背景情况:
- 集体电描述了电场下的细胞集体迁移.
- 在大型表皮细胞中观察到迁移速度的空间异质性.
研究的目的:
- 在上皮组织中建模集体电的空间异质性.
- 开发一个反应-对流-扩散模型用于电转动.
- 预测组织大小和几何结构对集体迁移的影响,并为控制的迁移模式设计电场.
主要方法:
- 开发了竞争的迁移线索的连续模型.
- 制定并验证了一种反应-对流-扩散模型.
- 在不同的条件下模拟MDCK单层电.
主要成果:
- 连续模型成功解释了速度异质性.
- 反应-对流-扩散模型准确地描述了表皮单层运动.
- 关于组织大小和几何学对迁移模式的影响,进行了预测.
结论:
- 电场设计可以控制集体迁移模式.
- 定制刺激协议可以为特定的应用设计.
- 这项工作为理解和操纵电动出租车提供了一个框架.
相关概念视频
Induced Electric Fields: Applications
1.6K
An important distinction exists between the electric field induced by a changing magnetic field and the electrostatic field produced by a fixed charge distribution. Specifically, the induced electric field is nonconservative because it does not work in moving a charge over a closed path. In contrast, the electrostatic field is conservative and does no net work over a closed path. Hence, electric potential can be associated with the electrostatic field but not the induced field. The following...
1.6K
State Space Representation
207
The frequency-domain technique, commonly used in analyzing and designing feedback control systems, is effective for linear, time-invariant systems. However, it falls short when dealing with nonlinear, time-varying, and multiple-input multiple-output systems. The time-domain or state-space approach addresses these limitations by utilizing state variables to construct simultaneous, first-order differential equations, known as state equations, for an nth-order system.
Consider an RLC circuit, a...
Consider an RLC circuit, a...
207
Electrostatic Boundary Conditions in Dielectrics
1.2K
When an electric field passes from one homogeneous medium to another, crossing the boundary between the two mediums imparts a discontinuity in the electric field. This results in electrostatic boundary conditions that depend on the type of mediums the field propagates through.
Consider a case where both the mediums across a boundary are two different dielectric materials. Recall that the electric field and electric displacement are proportional and related through the material's...
Consider a case where both the mediums across a boundary are two different dielectric materials. Recall that the electric field and electric displacement are proportional and related through the material's...
1.2K
Electrostatic Boundary Conditions
476
Consider an external electric field propagating through a homogeneous medium. When the electric field crosses the surface boundary of the medium, it undergoes a discontinuity. The electric field can be resolved into normal and tangential components. The amount by which the field changes at any boundary is given by the difference between the field components above and below the surface boundary.
The surface integral of an electric field is given by Gauss's law in integral form and is related to...
The surface integral of an electric field is given by Gauss's law in integral form and is related to...
476
Induced Electric Fields
3.7K
The fact that emfs are induced in circuits implies that work is being done on the conduction electrons in the wires. What can possibly be the source of this work? We know that it’s neither a battery nor a magnetic field, as a battery does not have to be present in a circuit where current is induced, and magnetic fields never do any work on moving charges. The source of the work is in fact an electric field that is induced in the wires. For example, if a stationary conductor is placed in a...
3.7K
Conservation of Energy in Control Volume
836
Consider a turbine operating under steady-flow conditions. The control volume is drawn around the turbine, with fluid entering at one point and exiting at another. The turbine extracts energy from the fluid, which performs mechanical work (shaft work).
For steady flow systems, the time derivative of the stored energy becomes zero since there is no energy accumulation within the control volume. This simplifies the energy equation to:
For steady flow systems, the time derivative of the stored energy becomes zero since there is no energy accumulation within the control volume. This simplifies the energy equation to:
836


