在未成熟的皮层网络中,模块化活动的自我组织
Haleigh N Mulholland1, Matthias Kaschube2, Gordon B Smith1,3
1Department of Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA.
bioRxiv : the preprint server for biology
|March 11, 2024
概括
发育中的大脑网络自发地将神经活动组织成模块化模式. 这项研究表明,局部激发与侧向抑制 (LE/LI) 连接驱动这种组织,形成感官图的基础.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 计算神经科学是一种神经科学.
背景情况:
- 在发育过程中,皮层活动形成模块化模式,这是成熟的柱状架构的前身.
- 具有局部激发和横向抑制 (LE/LI) 的循环神经网络在理论上被提出可以动态产生这种结构化的活动.
- 了解早期皮层组织背后的机制对于破译感官地图形成至关重要.
研究的目的:
- 实验验证LE/LI机制在组织早期皮质活动中的预测.
- 研究皮质网络如何对模式刺激和内在网络属性的反应.
- 探索自发活动,唤起活动和感官表现的发展之间的关系.
主要方法:
- 同时使用广场成像和光遗传学在眼睛打开前在青少年鹿皮质中使用.
- 使用不同空间波长的均和有模式的光遗传刺激来探测网络反应.
- 分析的重点是唤起皮层活动和自发活动结构的空间模式.
主要成果:
- 皮层网络将统一的刺激转化为具有特征空间波长的模块化模式.
- 在特征波长的光遗传刺激选择性偏差唤起的活动模式.
- 使用不同波长的刺激导致活动模式趋向于特征波长,表明网络受损.
- 早期自发皮质活动的结构反映了统一的光唤起活动,这表明了共享的潜在机制.
结论:
- 这些发现为LE/LI机制在组织早期皮质活动方面提供了直接的实验支持.
- 发育中的皮质表现出一种内在的倾向,即将神经活动组织成特定的模块化模式.
- 这种内在的组织机制对于大脑中有序的柱状地图和感官表征的形成至关重要.
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