视网膜特征的定量表征在翻译的OCTA中
Rashadul Hasan Badhon1, Atalie Carina Thompson2, Jennifer I Lim3
1Department of Electrical and Computer Engineering, University of North Carolina at Charlotte, Charlotte, NC, United States.
medRxiv : the preprint server for health sciences
|March 11, 2024
概括
生成机器学习可以将光学相干断层扫描 (OCT) 图像转换为光学相干断层扫描 (OCTA) 图像. 这种技术显示了视网膜疾病诊断的潜力,改善了可访问性,并降低了与专门的OCTA硬件相关的成本.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 机器学习 机器学习
背景情况:
- 光学连贯断层扫描血管造影 (OCTA) 对于诊断视网膜疾病至关重要,但需要专门的硬件,限制其广泛的临床采用.
- 生成型机器学习 (ML) 提供了一个潜在的解决方案,可以从标准光学连贯断层扫描 (OCT) 数据中创建类似OCTA的图像.
研究的目的:
- 探索使用生成式ML将标准OCT图像转换为OCTA图像 (TR-OCTA) 的可行性.
- 通过将其血管特征与基本真实性OCTA (GT-OCTA) 进行比较,评估TR-OCTA的诊断潜力.
主要方法:
- 实施了一个生成对抗性网络框架,包括2D血管细分和OCTA图像翻译模型.
- 使用了500名患者的公共数据集,图像按分辨率和疾病状态分类.
- 使用各种指标,TR-OCTA图像质量和血管特征与GT-OCTA进行了定量验证.
主要成果:
- TR-OCTA显示出高图像质量,与GT-OCTA在结构相似性和对比性方面相当.
- 血管指标显示出轻微的差异,特别是在患病的患者中,形度和血管周长指数表现优于密度特征.
- 该研究证实了使用TR-OCTA用于客观疾病诊断的可行性.
结论:
- 生成式ML提供了一种有希望的方法,可以从标准的OCT扫描中生成OCTA质量的图像.
- 对血管特征的TR-OCTA分析可以帮助检测视网膜疾病,克服目前OCTA采用的局限性.
- 这种方法提高了诊断能力,并减少了对昂贵的OCTA设备的依赖.
相关概念视频
01:28IR and UV–Vis Spectroscopy of Carboxylic Acids
In IR spectroscopy of carboxylic acids, the C=O bond shows a characteristic band between 1710 and 1760 cm⁻¹, and the O–H bond exhibits a broad band between 2500 and 3300 cm⁻¹.
However, the stretching absorptions for the C=O bond vary depending on the structure of carboxylic acids. The C=O bond of the free carboxylic acids shows a higher stretching frequency, 1760 cm−1, while H-bonded carboxylic acids (dimers) exhibit stretching absorptions at a lower frequency, 1710 cm−1. The C=O bond of the...
However, the stretching absorptions for the C=O bond vary depending on the structure of carboxylic acids. The C=O bond of the free carboxylic acids shows a higher stretching frequency, 1760 cm−1, while H-bonded carboxylic acids (dimers) exhibit stretching absorptions at a lower frequency, 1710 cm−1. The C=O bond of the...
01:26Spectroscopy of Carboxylic Acid Derivatives
Infrared spectroscopy is primarily used to determine the types of bonds and functional groups. In carboxylic acid derivatives, a typical carbonyl bond absorption is observed around 1650–1850 cm−1. For esters, the absorption is recorded at around 1740 cm−1, while acid halides show the absorption at about 1800 cm−1. Another acid derivative, the acid anhydrides, exhibit two carbonyl absorption around 1760 cm−1 and 1820 cm−1, arising from the symmetrical and unsymmetrical carbonyl vibration.
In the...
In the...