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热应激下的进化影响大肠杆菌对抗生素的耐药性

Austin Bullivant¹, Natalie Lozano-Huntelman¹, Kevin Tabibian¹

¹Department of Ecology and Evolutionary Biology, University of California, Los Angeles, USA.

bioRxiv : the preprint server for biology

|March 11, 2024

概括

在热应激下的演变令人惊的是,降低了大肠杆菌的最佳生长温度. 这种热进化也导致了抗生素耐药性的复杂变化,在生长和耐药性之间观察到的相关性很少.

科学领域:

微生物学微生物学
进化生物学进化生物学
细菌生理学细菌生理学

背景情况:

抗生素耐药性和温度变化可以引起类似的细菌反应.
抗生素压力可以改变细菌的最佳生长温度.
热应激进化的对抗生素耐药性的影响在很大程度上是未知的.

结论:

在热应激下的细菌进化可以意外地减少生长的最佳状态.
热应激适应以复杂的方式影响抗生素耐药性.
温度适应和抗生素耐药性之间的相互作用是复杂的,不能完全预测.

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