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Updated: Jul 1, 2025

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
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在结直肠腺瘤形成中对ACSS2的KRAS突变选择性要求

Konstantin Budyagan1, Alexa C Cannon1, Adam Chatoff2

  • 1Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America.

Research square
|March 11, 2024
PubMed
概括

结直肠癌 (CRC) 中不同的KRAS突变会影响细胞信号传递,特别是脂质代谢. G12V突变独特地调节胆固醇和脂质通路,为CRC治疗提供了新的治疗点.

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