Jove
Visualize
联系我们

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

ADELLE: A global testing method for trans-eQTL mapping.

PLoS genetics·2025
Same author

Overcoming the "feast or famine" effect: improved interaction testing in genome-wide association studies.

bioRxiv : the preprint server for biology·2024
Same author

JASPER: fast, powerful, multitrait association testing in structured samples gives insight on pleiotropy in gene expression.

bioRxiv : the preprint server for biology·2024
Same author

BRASS: Permutation methods for binary traits in genetic association studies with structured samples.

PLoS genetics·2023
Same author

Genome wide association analysis in a mouse advanced intercross line.

Nature communications·2018
Same journal

Genetic Impacts on Variability of Body Fat Distribution Uncover Gene-Environment and Gene-Gene Interactions.

bioRxiv : the preprint server for biology·2026
Same journal

16S ribosomal RNA modification drives transcript-specific translation efficiency.

bioRxiv : the preprint server for biology·2026
Same journal

FlcE latches onto the FliL-stator complex to turbocharge flagellar motility in <i>Borrelia burgdorferi</i>.

bioRxiv : the preprint server for biology·2026
Same journal

Synaptic pruning, myelination and the emergence of psychiatric disorders in late adolescence.

bioRxiv : the preprint server for biology·2026
Same journal

Structural and functional insights into the Rcs phosphorelay.

bioRxiv : the preprint server for biology·2026
Same journal

The structural basis of RanGAP1 regulation and catalysis in nuclear transport.

bioRxiv : the preprint server for biology·2026
查看所有相关文章
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jun 30, 2026

In vitro tRNA Methylation Assay with the Entamoeba histolytica DNA and tRNA Methyltransferase Dnmt2 (Ehmeth) Enzyme
12:36

In vitro tRNA Methylation Assay with the Entamoeba histolytica DNA and tRNA Methyltransferase Dnmt2 (Ehmeth) Enzyme

Published on: October 19, 2010

ADELLE:一个全球测试方法,用于Trans-eQTL映射.

Takintayo Akinbiyi, Mary Sara McPeek, Mark Abney

    bioRxiv : the preprint server for biology
    |March 11, 2024
    PubMed
    概括
    此摘要是机器生成的。

    发现远程遗传调节器 (跨eQTLs) 是一个挑战. 使用总结统计数据的新统计框架ADELLE显著改善了对这些关键基因表达调节者的检测.

    更多相关视频

    Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project
    10:19

    Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project

    Published on: April 8, 2017

    Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq
    09:08

    Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq

    Published on: November 13, 2017

    相关实验视频

    Last Updated: Jun 30, 2026

    In vitro tRNA Methylation Assay with the Entamoeba histolytica DNA and tRNA Methyltransferase Dnmt2 (Ehmeth) Enzyme
    12:36

    In vitro tRNA Methylation Assay with the Entamoeba histolytica DNA and tRNA Methyltransferase Dnmt2 (Ehmeth) Enzyme

    Published on: October 19, 2010

    Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project
    10:19

    Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project

    Published on: April 8, 2017

    Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq
    09:08

    Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq

    Published on: November 13, 2017

    科学领域:

    • 遗传学 是一个遗传学.
    • 生物信息学是一种生物信息学.
    • 系统生物学 系统生物学

    背景情况:

    • 了解基因表达调节是复杂的.
    • 基因附近的cis-eQTL很容易发现,但远离基因的trans-eQTL更难识别.
    • 跨eQTLs对遗传性有很大的贡献,但由于统计方面的挑战,它们被发现不足.

    研究的目的:

    • 开发一种强大的统计方法来识别跨-eQTLs.
    • 克服与多个基因表达水平相关的SNP检测的局限性.

    主要方法:

    • 提出了ADELLE,一个仅使用汇总统计数据的统计框架.
    • 设计ADELLE对影响多个基因表达特征的SNP敏感.
    • 通过模拟和小鼠数据集对其他六种方法进行了ADELLE的评估.

    主要成果:

    • 与现有方法相比,ADELLE在检测与10,000个特征中的0.1%-2%相关的SNP方面表现出更强的力量.
    • 在小鼠数据中,ADELLE发现了显著的跨eQTL,这些数据在标准分析中错过了.
    • 该框架对于与多个基因表达水平相关的SNP特别有效.

    结论:

    • ADELLE是一个强大而有效的工具,用于发现基因表达的跨调节者.
    • 该方法有助于发现复杂的遗传调节机制.
    • 通过使用总结统计数据,ADELLE为跨eQTL映射提供了显著的改进.