使用基因组结构方程建模,对行为抑制和物质使用 (障碍) 的基因组组件进行分区
Tanya B Horwitz1,2, Katerina Zorina-Lichtenwalter1, Daniel E Gustavson1
1Institute for Behavioral Genetics, University of Colorado Boulder, 1480 30 St, Boulder, CO, United States of America 80303.
medRxiv : the preprint server for health sciences
|March 11, 2024
概括
遗传研究表明,外部化行为,包括物质使用 (SU) 和物质使用障碍 (SUD),具有显著的遗传重叠. 然而,特定于行为失禁 (BD) 的基因组变异的一个明显部分存在于SU和SUD之间.
科学领域:
- 行为遗传学 行为遗传学
- 精神病学基因组学 精神病学基因学
- 成研究 研究成研究
背景情况:
- 外向化行为,包括冒险和冲动性,与物质使用 (SU) 和物质使用障碍 (SUD) 一起被研究.
- 以前的研究表明,SU,SUD和行为失禁 (BD) 特征之间有共同的遗传架构.
- 了解这些重叠而又独特的特征的遗传基础对于开发有针对性的干预措施至关重要.
结论:
- 行为抑制,物质使用和物质使用障碍在遗传上高度相关.
- 基因组变异的一个重要,非共享的组成部分是行为抑制的基础.
- 对BD特异性遗传变异的进一步研究可能会揭示新的分子相关物和治疗点.
更多相关视频
相关概念视频
Human Genetics
566
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
566
Behavioral Genetics and Its Designs
366
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
366
Biological Causes of Schizophrenia
57
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
57
Substance Use Disorders Affecting Sleep
167
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
167


