在条形体中调节性内神经元的分布和密度的性别差异
Meghan Van Zandt1, Deirdre Flanagan1, Christopher Pittenger1,2,3,4,5
1Pittenger Laboratory, Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.
bioRxiv : the preprint server for biology
|March 11, 2024
概括
男人比女人在条形体中具有更多的胆能内神经元 (CIN) 和快速升的内神经元 (FSI),这可能解释了图雷特综合征等神经精神疾病中的性别差异.
科学领域:
- 神经科学是一个神经科学.
- 神经解剖学是一个神经解剖学.
- 大脑中的性别差异
背景情况:
- 皮质 - 基底质回路功能障碍与具有显著性别差异的神经精神疾病有关,例如自闭症和图雷特综合征 (TS).
- 特定的内部神经元,包括胆性内部神经元 (CINs) 和表达双蛋白的快速激增内部神经元 (FSIs),都与TS有关,它们的切除会导致雄性小鼠的行为问题,但不是雌性小鼠.
结论:
- 在状CIN和FSI的密度和分布方面存在显著的性别差异.
- 这些神经解剖学变异可能是基底腺功能性别特异性的基础.
- 这些发现有助于理解神经精神疾病中性别差异的神经生物学基础.
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