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Updated: Jul 1, 2025

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes
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Nir1-LNS2是一种新型的酸生物传感器,可以揭示脂质生产的机制

Claire C Weckerly1, Taylor A Rahn2, Max Ehrlich1

  • 1Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

bioRxiv : the preprint server for biology
|March 11, 2024
PubMed
概括

研究人员开发了一种新工具Nir1-LNS2,用于跟踪活细胞中的酸 (PA). 这种敏感的生物传感器可视化PA动态和生产,帮助脂质研究.

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Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
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