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MDR1rs1045642多态和乳腺癌风险之间的关联:更新的元分析

Lili Gong¹, Gang Hu¹, Lihua Xu¹

¹Department of Breast Surgery Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430016, P.R. China.

Oncology letters

|March 11, 2024

概括

MDR1 rs1045642基因多态性与整体乳腺癌风险无关. 然而,它可能会增加亚洲人群的风险,并在混合种族中降低风险.

科学领域:

遗传学遗传学是一个
在瘤学瘤学.
药物基因组学药物基因组学

背景情况:

多药耐药性1 (MDR1) 基因编码了一个依赖ATP的排泄,这对于癌症治疗中药物运输至关重要.
已经研究了MDR1基因的突变,特别是rs1045642多态,以确定它们与癌症发病率的潜在关联.
之前对MDR1rs1045642多态和乳腺癌风险的研究已经产生了不一致的结果.

研究的目的:

使用元分析系统地评估MDR1rs1045642多态和乳腺癌风险之间的关联.
为了澄清关于MDR1 rs1045642多态性及其对乳腺癌易感性影响的相互矛盾的发现.

主要方法:

对21个已发表的病例研究进行了元分析,其中包括6815名乳腺癌患者和9227名健康对照.
分析了截至2023年8月16日的数据,以评估MDR1 rs1045642多态与乳腺癌风险的整体和子组关联.
统计分析包括赔率比率 (OR),95%置信区间 (CI) 和异质性评估 (I2).

主要成果:

总的来说,MDR1 rs1045642多态性与乳腺癌风险没有显著关联.
亚组分析显示,在具有TT基因型的亚洲人群中,乳腺癌风险明显更高 (递归模型:OR=1.393,P=0.001).
在混合种族人群中,MDR1 C3435T多态性与乳腺癌发病率降低有关 (OR=0.578,P=0.006),但在白人中并非如此.

结论:

在不同族群中,MDR1 rs1045642多态可能会对乳腺癌风险产生不同的影响.
在亚洲人群中观察到潜在的风险增加,而在混合种族群体中观察到风险降低.
在高加索人群中没有发现任何显著的关联,这凸显了乳腺癌研究中需要进行特定种族的遗传分析的需要.

关键词:

乳腺癌乳腺癌乳腺癌遗传多形态主义是一种遗传多形态主义.多药性耐药性 1 rs1045642 的情况

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