血清瘤标志物表达 (CA199,CA242和CEA) 以及其对2型糖尿病的临床影响
1Department of Endocrinology, Hefei BOE Hospital, Hefei 230013, Anhui Province, China.
World journal of diabetes
|March 11, 2024
概括
患有2型糖尿病 (T2DM) 的患者表现出CEA和CA199.9等血清瘤标志物的升高. 血糖和HbA1c水平与这些标志物相关,建议对血糖控制不佳的患者进行查.
科学领域:
- 内分泌学和新陈代谢学
- 瘤学生物标志物
背景情况:
- 2型糖尿病 (T2DM) 中的葡萄糖和脂质代谢障碍与血清消化道瘤标志物水平有关.
- 瘤标志物在治疗T2DM患者中具有临床意义.
研究的目的:
- 在T2DM患者中评估血清瘤标志物表达 (CA199,CA242,CEA).
- 确定这些瘤标志物在T2DM中的临床影响.
主要方法:
- 这是一项对82名T2DM患者和51名对照组的观察研究.
- 测量了禁食血糖 (FBG),糖化血红蛋白 (HbA1c) 和瘤标志物 (CA199,CEA,CA242).
- 与瘤标志物水平相关联的FBG和HbA1c;用于HbA1c> 9%的患者的诊断准确性ROC曲线.
主要成果:
- 与对照组相比,T2DM患者的血清FBG,HbA1c,CA199和CEA水平较高.
- 在T2DM组之间观察到CEA和CA199水平的显著差异,HbA1c ≤9%和>9%.
- CA199,CEA和CA242的水平与HbA1c和FBG有积极的相关性.
结论:
- 与对照组相比,T2DM患者的血清CEA和CA199水平较高.
- HbA1c和FBG水平显示与CA199,CEA和CA242.2的相关性.
- 对于血糖控制不良的T2DM患者,建议进行瘤标志物查.
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