在接下来的怀孕中,在Tdap疫苗接种后,在分娩时的免疫性
Louise De Weerdt1, Anaïs Thiriard2, Elke Leuridan1
1Centre for the Evaluation of Vaccination, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium.
Frontiers in immunology
|March 11, 2024
概括
在连续怀孕中重复接种, diphtheria 和非细胞性百日咳 (Tdap) 疫苗显示第二次怀孕中对胎儿的抗体转移减少. 每次怀孕Tdap疫苗接种对于孕产妇和婴儿的免疫力至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 推在每次怀孕期间接种疹,白喉,非细胞性百日咳 (Tdap) 疫苗.
- 以前的研究证实了产前Tdap疫苗接种的安全性.
- 在两个连续怀孕期间,Tdap疫苗接种的免疫性尚未得到充分证实.
研究的目的:
- 在连续怀孕中重复接种Tdap疫苗后,调查Tdap特异性免疫和胎盘转移.
- 为了比较抗体水平和第一次和第二次怀孕之间的转移比率.
主要方法:
- 包括在两个连续怀孕中接种Tdap疫苗的妇女.
- 使用多重免疫试验量化了Tdap特定的总IgG和IgG子类.
- 分析了母体和带血清样本.
主要成果:
- 分析了27名女性,分娩间隔平均为2.4年.
- 在这两次怀孕中,母亲的IgG水平相似,但在第二次怀孕中,带IgG水平下降.
- 在第二次怀孕中,总IgG和IgG1的胎盘转移比率通常较低.
结论:
- 这项研究是首次报告Tdap特异性抗体水平和在连续怀孕中重复接种疫苗后的转移.
- 在第二次怀孕中观察到Tdap特异性IgG和IgG1抗体的转移减少.
- 虽然Tdap疫苗接种在每次怀孕中都是有益的,因为百日咳免疫力下降,但需要进一步研究密切间隔的增强剂对婴儿保护的影响.
关键词:
的IgG子类的IgG子类.Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap Tdap母亲的抗体对母体的抗体.连续怀孕的情况.通过胎盘的转移.相关概念视频
Development of Immunocompetence
307
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
307
Vaccinations
44.5K
Overview
44.5K
Immunological Memory
611
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
611
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Active versus Passive Immunity
642
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Active Immunity
Active immunity refers to the resistance one develops...
642


