免疫细胞在骨转移性癌症微环境中的多重影响瘤
Shixin Chen1,2,3,4, Jiangchu Lei1,2,3,4, Haochen Mou1,2,3,4
1Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Frontiers in immunology
|March 11, 2024
概括
本综述探讨了骨转移性癌症的微环境,详细介绍了免疫和骨细胞在瘤进展和休眠中的作用. 它强调了骨转移的新兴免疫疗法,解决了当前的挑战和未来的机会.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 骨是固体瘤转移的常见地点,导致预后不佳和复发率高.
- 骨转移性微环境,包括免疫和骨细胞,显著影响瘤的行为和治疗耐药性.
研究的目的:
- 审查免疫和骨细胞在骨转移中的多方面的作用.
- 检查免疫微环境对瘤休眠期的影响.
- 讨论新兴的免疫疗法和治疗骨转移性恶性瘤的未来方向.
主要方法:
- 文献综述侧重于淋巴细胞,髓状细胞 (巨细胞,MDSC,树突细胞,巨核细胞) 和骨细胞 (骨质细胞,骨质母细胞).
- 分析免疫细胞与瘤细胞的相互作用及其对转移的贡献.
- 评估免疫微环境在瘤休眠期和治疗反应中的作用.
主要成果:
- 淋巴细胞有助于瘤的扩散,入侵,生长和骨转移中的潜在根除.
- 骨髓状细胞和骨细胞 (骨质细胞,骨质细胞) 创建一个"恶性循环",加速骨解性骨转移.
- 免疫微环境在调节骨中瘤休眠的过程中起着至关重要的作用.
结论:
- 了解骨转移性微环境对于开发有效疗法至关重要.
- 新兴的免疫疗法显示出希望,但在临床应用中面临挑战.
- 需要对免疫介导机制和向治疗进行进一步的研究,以改善骨转移患者的治疗结果.
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