使用动力模型对微生物生物表面活性剂生产的早期过程优化进行生命周期评估 - - 一个关于曼诺西利利利醇脂 (MEL) 的案例研究
Lars Bippus1, Ann-Kathrin Briem1,2, Alexander Beck3,4
1Department Life Cycle Engineering GaBi, Institute for Acoustics and Building Physics IABP, University of Stuttgart, Stuttgart, Germany.
Frontiers in bioengineering and biotechnology
|March 11, 2024
概括
曼诺西利利醇脂类 (MELs) 生产的生命周期评估 (LCA) 揭示了基质供应和生物反应器通风是关键的环境影响热点. 过程优化可以显著提高这些微生物生物表面活性剂的可持续性.
科学领域:
- 生物技术和工业微生物学
- 环境科学与工程环境科学与工程
- 可持续化学 可持续化学
背景情况:
- 曼诺赛利利醇脂 (MELs) 是微生物生物表面活性剂,具有多种应用,通过真菌发酵产生.
- 早期生命周期评估 (LCA) 对于优化生物技术产品 (如MELs) 的环境可持续性至关重要.
- 目前的生产方法需要优化,以尽量减少环境足迹.
研究的目的:
- 进行一个全面的生命周期评估 (LCA) 的曼诺西利利利醇脂类 (MELs) 产量.
- 在MELs生产过程中识别环境影响热点,以进行有针对性的优化.
- 支持开发用于生物表面活性剂制造的更可持续的生物技术过程.
主要方法:
- 使用环境足迹 (EF) 3.1 影响评估方法进行了摇篮到门的生命周期评估 (LCA).
- LCA模型基于10 m3尺度发酵和净化过程的高级实验数据.
- 关键的输入包括菜油和葡萄糖作为基质,净化包括分离,溶剂提取和染色学.
主要成果:
- 基质供应对环境影响做出了重大贡献,在酸性化和轻质化等类别中占比超过70%.
- 生物反应器通风 (33%) 和净化过程 (42%) 的能源是气候变化影响的主要贡献者.
- 在下游加工中使用的溶剂被确定为大多数环境影响类别的主要贡献者.
结论:
- 优化基质采购,提高生物反应器通风效率,改善净化中的溶剂使用对于减少MEL生产对环境的影响至关重要.
- 场景分析和动态LCA为工艺工程师提供了有价值的见解,以实现环境可持续性.
- 这项LCA研究表明,开发更环保的生物表面活性剂生产工艺具有重大潜力.
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