慢性病患者认知障碍的危险因素
Xiao-Hui Wang1, Yong He1, Huan Zhou1
1Department of Nephrology, The Fifth Hospital of Wuhan, Wuhan 430050, Hubei Province, China.
World journal of psychiatry
|March 11, 2024
概括
认知功能障碍在慢性病 (CKD) 患者中很常见. 高龄,低学历,离婚/寡妇身份,自我资助和高血压增加了CKD患者的风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 慢性病 (CKD) 与认知功能障碍有关,这对公众健康造成了重大关注.
- 之前的研究强调,CKD患者的认知障碍风险增加.
研究的目的:
- 在被诊断为CKD的患者中,确定与并发性认知功能障碍相关的关键风险因素.
- 这项研究旨在为CKD患者的认知健康提供有针对性的干预措施.
主要方法:
- 从2021年10月到2023年3月进行了一项前性队列研究,涉及CKD患者.
- 数据收集使用了通过文献审查和专家咨询开发的问卷,涵盖人口统计和健康状况.
- 关键变量包括年龄,教育,收入,婚姻状况,生活条件,支付方式和高血压.
主要成果:
- 年龄较大 (60-79岁和≥80岁),教育程度较低 (小学或以下),离婚/寡妇身份以及自筹支付方式与较高的认知障碍几率有关.
- 高血压显著增加了CKD患者认知功能障碍的风险 (OR = 2.011).
- 相反,高等教育 (大学学位) 和结婚与认知障碍风险降低有关.
结论:
- 在CKD患者中,认知功能障碍的重大风险因素包括晚年,较低的教育水平,离婚或丧偶的婚姻状况和自我资助的支付.
- 高血压的存在是加剧这一群体认知障碍风险的关键因素.
- 这些发现强调了CKD认知衰退的多因素性质,并突出了临床关注的领域.
相关概念视频
01:17Factors Affecting Renal Clearance: Renal Impairment
91
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
91
01:11Renal Failure: Dose Adjustments
88
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
88
01:10Nephrons
2.4K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.4K
01:31Factors Affecting Renal Clearance: Drug's Physicochemical Properties and Plasma Levels
223
Renal clearance of a drug is influenced by various factors, including its physicochemical properties and plasma levels. These factors play a significant role in determining how efficiently the kidneys eliminate a drug.
One important factor is the drug's molecular size. The kidneys readily excrete smaller molecules below 300 Daltons (Da). On the other hand, molecules weighing between 300 and 500 Da are excreted through both urine and bile. Larger molecules above 500 Da tend to be excreted...
One important factor is the drug's molecular size. The kidneys readily excrete smaller molecules below 300 Daltons (Da). On the other hand, molecules weighing between 300 and 500 Da are excreted through both urine and bile. Larger molecules above 500 Da tend to be excreted...
223
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
125
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
125
01:20Renal Corpuscle
2.1K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
2.1K