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睡眠不足对大脑功能的改变:一个基于坐标的休息状态功能磁共振成像元分析
Qin Zhang1,2, Yong-Zhe Hou3, Hui Ding4
1Department of Radiology, The Second People's Hospital of Guizhou Province, Guiyang 550000, Guizhou Province, China.
World journal of psychiatry
|March 11, 2024
概括
缺乏睡眠会显著改变大脑功能,特别是在中侧额头和大脑体中. 这一元分析阐明了由于睡眠丧失而导致的一致的神经变化,影响认知表现.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 医疗成像医学成像
背景情况:
- 睡眠不足是影响认知能力的普遍问题.
- 现有的睡眠损失神经成像研究显示出不一致的结果.
- 缺乏睡眠导致的持续的大脑功能变化需要进行调查.
研究的目的:
- 系统地识别与睡眠剥夺有关的一致的大脑功能变化.
- 使用神经成像数据库的元分析来解决不一致的问题.
- 根据fMRI数据,就业签名差分映射 (SDM) 和激活概率估计 (ALE).
主要方法:
- 按照PRISMA指南进行系统的文献搜索.
- 包括健康受试者与急性睡眠剥夺和全脑fMRI数据的研究.
- 使用SDM和ALE进行的21项选定的研究的元分析.
主要成果:
- 对21项研究 (23项实验,498名受试者) 的分析显示了显著的变化.
- 在睡眠剥夺后,右脑体灰质增加.
- 观察到左侧中枢前回形和左侧下叶片的活性下降.
结论:
- 这一元分析证实了睡眠不足影响的特定大脑区域.
- 关键受影响的区域包括左中侧额头和体.
- 研究结果提供了关于睡眠丧失的神经病理学和神经学影响的见解.
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