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在接受选择性手术的患者中,Omicron变异感染对肝脏,脏和凝血系统的影响:一项回顾性病例控制研究

Xiaojuan Xiong¹, Rui Li¹, Haoyu Pei¹

¹Department of Anesthesiology, Army Medical Center of PLA, Daping Hospital, Army Medical University, 10 ChangjiangZhilu, Yuzhong District, Chongqing 400042, China.

International journal of medical sciences

|March 11, 2024

概括

在选择性手术患者中,Omicron变异感染对外科手术期间器官功能的影响很小. 手术后的结果,如死亡率和住院时间,在感染后一个月保持不变.

科学领域:

麻醉学和外科手术期间的医学.
传染性疾病传染性疾病
免疫学免疫学免疫学

背景情况:

SARS-CoV-2 的 Omicron 变种已经成为一个重大的全球健康问题.
了解它对接受手术的患者的影响对于术后管理至关重要.
之前的研究已经探讨了COVID-19对外科手术结果的影响,但Omicron特定数据有限.

研究的目的:

调查Omicron变种感染对接受选择性手术的患者外科手术期间器官功能的影响.
为了比较手术前一个月感染Omicron的患者与未感染的对照人群之间的器官功能指标.
分析瘤和非瘤子组内结果的潜在差异.

主要方法:

分析了5029名接受选择性手术的患者队列.
患者被分为一个感染Omicron的组 (2022年12月至2023年1月) 和一个控制组 (2022年10月至11月).
经手术期间关于凝血,肝功能,全血细胞计 (CBC) 和功能的数据被采集并使用二进制逻辑回归来分析.

主要成果:

与未感染患者相比,感染Omicron的患者在手术前和手术后的器官功能标志物中显示出最小的变化.
具体的变化包括增加的前热血素活性 (PTa),纤维素和血小板 (PLT),以及降低的氨酸转移酶 (ALT) 和白细胞计数 (WBC).
两组之间没有观察到死亡率或住院时间 (LOS) 的显著差异.

结论:

在Omicron变种感染一个月后进行的选择性手术与最小的外科手术期间器官功能变化有关.
关键的实验室参数和临床结果,如死亡率和LOS没有显著影响.
这些发现表明,当Omicron感染得到适当的管理时,可能不会对选择性手术患者在器官功能和手术后的直接结果方面构成重大风险.

关键词:

这种Omicron变异是什么?凝固的参数凝固参数全血细胞计数的完整数目.选择性外科手术是一种选择性手术.功能功能功能肝功能肝功能肝功能

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