波动和稳定的高温不同影响雌性幼鱼的生殖内分泌学
M J Housh1, J Telish2, K L Forsgren2
1Biological Sciences Department, Center for Coastal Marine Sciences, California Polytechnic State University, San Luis Obispo, CA 93407, USA.
Integrative organismal biology (Oxford, England)
|March 11, 2024
概括
升高的温度会破坏雌性阿马尔戈萨河鱼的生殖功能,因为它会破坏卵巢的类固醇生成并减少卵子的产生. 恒定的高温和波动的热量都会对鱼类的繁殖产生负面影响.
科学领域:
- 生殖生理学 生殖生理学
- 环境毒理学环境毒理学
- 内分泌学 在内分泌学.
背景情况:
- 鱼类的生殖功能对温度敏感,升高的温度会影响雌性体的发育和行为.
- 高温会影响下丘脑 - 垂体 - 淋巴腺 (HPG) 轴和类固醇生成,但对恒定热和波动热的反应尚不清楚.
研究的目的:
- 为了研究稳定的高和波动温度对HPG轴,卵巢功能和肝脏基因表达在雌性阿马戈萨河鱼 (C. n. 黄树 (英语:amargosae) 是一种红色的植物.
主要方法:
- 性成熟的幼鱼被暴露在稳定的25°C,波动的27-35°C或稳定的35°C中50天.
- 评估的淋巴体指数,卵细胞发育,卵巢和肝脏基因表达 (包括star,cyp11a1,3bhsd,11bhsd,shbg,cyp19a1a,esr2a),以及循环中的17β-雌激醇 (E2).
主要成果:
- 波动和稳定的高温都降低了淋巴体指数和生性卵细胞.
- 卵巢类固醇基因表达 (star,cyp11a1,3bhsd) 在两种热处理中都下降,而11bhsd和shbg在稳定的35°C中增加.
- 在两种热条件下,肝胆原蛋白和肝原蛋白mRNA水平都被下调,在稳定的35°C组中esr2a和shbg升高.
结论:
- 高温,无论是恒定还是波动,都会损害卵巢类固醇生成,并降低雌性幼鱼的卵膜和维原蛋白生产.
- 不同的热状态对生殖内分泌通路产生不同的影响,突出显示了温度对鱼类繁殖的影响的复杂性.
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