堵塞漏洞:在缺乏资源的环境中,人类与动物之间的接口存在抗生素耐药性
Maya L Nadimpalli1,2, Marc Stegger3,4,5, Roberto Viau2,6
1Gangarosa Department of Environmental Health, Emory Rollins School of Public Health, Atlanta, GA.
概括
卫生条件和卫生条件差,通过使细菌在人与动物之间传播,扩大了抗生素耐药性. 解决这些环境因素对于控制耐药病原体至关重要,特别是在中等收入国家.
科学领域:
- 微生物学 微生物学
- 公共卫生 公共卫生
- 环境科学 环境科学
背景情况:
- 抗生素耐药性是全球主要的健康威胁.
- 目前的战略重点是药物开发和减少滥用抗生素.
- 环境因素,特别是卫生条件和卫生条件差,可能会对抗药性传播产生重大影响.
研究的目的:
- 研究人类-动物细菌流在抗生素耐药性的作用.
- 为了比较来自柬埔寨的人类和肉类中的大肠杆菌中的移动耐药性元素.
- 评估环境控制对耐药性传播的影响.
主要方法:
- 在柬埔寨从人类和肉类来源收集了大肠杆菌样本.
- 分析了移动电阻元素和转位区域.
- 人类和动物分离物之间的基因元素比较.
主要成果:
- 在人类和动物中发现了相同的移动抵抗元素广泛分散.
- 在人类和动物 *E. coli* 种群中观察到一个保存的转子子子区域.
- 这种广泛的抵抗要素共享在高收入环境中并不常见.
结论:
- 不良的环境控制有助于抗生素耐药性在人类和动物之间扩散.
- 人与动物之间的接口是抵抗的出现和传播的关键点.
- 改善水,卫生和卫生基础设施对于打击低收入和中等收入国家的抗生素耐药性至关重要.
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