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具有特异性矮身的儿童与正常身高的兄弟姐妹有显著不同的肠道微生物群:一个病例对照研究

Liora Lazar^1,2, Adi Eshel³, Lelyan Moadi³

¹School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.

Frontiers in endocrinology

|March 11, 2024

概括

肠道微生物群的差异,特别是较高的Euryarchaeota和Methanobrevibacter水平,与儿童的特异性矮身 (ISS) 有关. 这些发现表明肠道细菌可能会影响线性生长,并为个性化治疗提供点.

科学领域:

微生物学微生物学
儿科内分泌学儿科内分泌学
遗传学遗传学是一个

背景情况:

异常性矮身 (ISS) 是一种儿童显著低于平均水平的情况,没有明确的医学原因.
肠道微生物群 (GM) 在宿主新陈代谢和发育中起着至关重要的作用,但其在国际空间站病原发生中的具体参与尚未得到充分理解.

研究的目的:

调查肠道微生物群在异常性矮身 (ISS) 病原发生中的作用.
为了比较ISS儿童的肠道微生物组成与他们正常身高的兄弟姐妹的肠道微生物组成.

主要方法:

一项涉及30对青春期前兄弟姐妹 (3-10岁) 的病例控制研究,其中有一对 ISS 和一个正常身高的兄弟姐妹.
用16S rRNA测序和代谢学分析了便样本以确定肠道微生物群的组成.
从国际空间站儿童和对照中进行便移植后,监测了无菌小鼠的生长.

主要成果:

患有ISS的儿童表现出更高的预测基因水平,用于pyrimidine,purin,flavin和thiamine生物合成.
在患有ISS的儿童中,Euryarchaeota类的流行率明显更高 (p<0.001).
在国际空间站儿童中,甲生物菌的较高水平与更矮的身高相关 (p=0.022),尽管接受它们的微生物群的小鼠没有表现出发育迟缓.

结论:

肠道微生物群的组成可能导致ISS儿童线性生长的变化.
在国际空间站中*Methanobrevibacter*的特殊作用需要进一步研究,突出增长变化的多因素性质.
针对特定的肠道微生物群落,可以提供个性化的治疗策略,以改善ISS儿童的生长.

关键词:

孩子们的孩子们的孩子们的孩子们.没有细菌的小鼠.肠道新陈代谢肠道新陈代谢我们的肠道微生物群.异常发病的矮个体的人.在甲上生存的细菌.

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