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血液学指数用于识别儿科重症监护室的儿童的不良结果

Sivakumar Mahalingam¹, Vikram Bhaskar¹, Prerna Batra²

¹Pediatrics, University College of Medical Sciences, Delhi, IND.

|March 11, 2024

概括

血小板-淋巴细胞比率 (PLR) 和中性粒细胞-淋巴细胞比率 (NLR) 等血液学指数显示,在儿科重症监护病房 (PICU) 预测死亡率的潜力. 需要进一步的研究来验证它们在儿童中的使用.

科学领域:

儿科重症监护医药儿科重症监护医药
血液学血液学血液学
生物标志物研究的研究.

背景情况:

儿童重症监护室 (PICU) 在发展中国家的死亡率更高.
早期识别重病儿童对于预防死亡至关重要.
像PLR和NLR这样的血液学指数在成年人中使用,但缺乏儿科验证.

研究的目的:

评估血液学指数在预测入住PICU的儿童死亡率方面的有效性.
评估血小板-淋巴细胞比率 (PLR),中性粒细胞-淋巴细胞比率 (NLR) 和血小板计数与平均血小板体积比率 (PLT/MPV) 在确定不良结果中的作用.

主要方法:

在第三级护理医院进行前性观察研究.
被录取的1-12岁儿童被录取到PICU.
排除了最近接受过输血产品,长期服用影响骨髓的药物或已知的血液学疾病的患者.

主要成果:

在275名患者中,有119名 (43.3%) 死亡.
在死亡率预测方面,PLR显示出高灵敏度 (85.71%),NLR显示出高特异性 (92.31%).
对于这些参数,没有观察到曲线下的显著区域 (AUC);PLT/MPV显示出有限的预测值.

结论:

血液学参数在全球范围内用于ICU死亡率预测.
PLR和NLR是具有成本效益的生物标志物,其比率可能优于单个标志物.
需要对分层样本进行进一步的研究,以确认血液学标记在儿科PICU死亡风险评估中的作用.

关键词:

血液学指数血液学指数中性粒细胞与淋巴细胞的比例 (nlr)儿科重症监护室 (PICU) 的儿童重症监护室儿科死亡率儿科死亡率血小板与淋巴细胞的比率 (plr)

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