银纳米颗粒的生物合成来自海洋ActinobacteriumMicromonospora sp.的银纳米颗粒. 和它们的生物活性潜力
Keshav Rajesh1, Sivaperumal Pitchiah2, Kamala Kannan1
1Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS) Saveetha University, Chennai, IND.
Cureus
|March 11, 2024
概括
海洋动态细菌合成了具有显著抗微生物和抗氧化特性的银纳米粒子. 这些生物合成的纳米颗粒有效抑制常见的病原体,如Streptococcus mutans和Staphylococcus aureus,同时也减少自由基.
科学领域:
- 纳米技术 纳米技术
- 微生物学 微生物学
- 环境科学 环境科学
背景情况:
- 纳米颗粒的生物合成为传统方法提供了一个环保,成本效益和可扩展的替代方案.
- 生物纳米颗粒显示出增强的水溶性和生物相容性.
- 微生物介导生物合成利用微生物的降解能力进行金属离子合成.
研究的目的:
- 评估由海洋动态细菌合成的银纳米粒子 (AgNPs) 的抗菌和抗氧化活性.
- 研究AgNP对临床病原体的疗效.
主要方法:
- 从海洋沉积物中分离和识别行为细菌.
- 使用*Micromonospora* sp.的无细胞提取物合成银纳米粒子.
- 通过对*Streptococcus mutans*,*Klebsiella pneumonia*和*Staphylococcus aureus*进行磁盘扩散来评估抗菌活性.
- 使用氨基基试验评估的抗氧化活性.
主要成果:
- 获得了五种动态细菌分离物;MBIT-MSA4合成了AgNPs.
- 合成的AgNP显示出对*S.mutans* (6毫米区),*K.肺炎* (10毫米区) 和*S. aureus* (8毫米区) 的抗菌活性.
- 这些AgNP表现出显著的抗氧化活性,抑制了73%的自由基.
结论:
- 通过海洋微生物介导的银纳米颗粒具有强大的抗微生物特性,可以对抗*S. mutans*和耐甲林*金黄色葡萄球菌 (MRSA).
- 这些生物合成的AgNP表现出显著的抗氧化活性,减少氧化应激.
- 这项研究强调了海洋动态细菌在生产有效的抗微生物和抗氧化剂银纳米颗粒方面的潜力.
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