坎迪达菌中的抗真菌药物耐药性:特别强调安福特素B
Lailema Ahmady1, Manisha Gothwal1, Muhammed Mushthaque Mukkoli1
1Department of Biochemistry, School of Basic Sciences, Central University of Punjab, Bathinda, India.
概括
来自Candida物种的侵入性真菌感染正在增加,特别是在脆弱的患者中. 本综述侧重于Candida的抗真菌药物耐药性,特别是安二B耐药性机制.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 由Candida物种引起的侵入性真菌感染正在增加,特别是在免疫受损和重症患者中,导致显著的发病率和死亡率.
- 导致这一增长的因素包括人口老龄化,免疫抑制药物的使用增加以及免疫性疾病的流行率.
- 虽然Candida albicans是最常见的,但非白虫的Candida物种也是重要的病原体.
研究的目的:
- 审查Candida物种当前抗真菌药物耐药性的情况.
- 专注于对安福特素B (AmB) 的耐药性机制.
- 为了突出治疗入侵性真菌感染的挑战,由于新兴的耐药性.
主要方法:
- 在Candida物种中对抗真菌药物耐药性的文献综述.
- 专注于安福特里辛B (AmB) 作为一种关键的抗真菌剂.
- 对AmB耐药性背后的机制的分析,包括对ergosterol的改变.
主要成果:
- 坎迪达菌种对可用的抗真菌药物表现出耐药性,使治疗复杂化.
- 抗 B 氨基氨酸耐药性主要与真菌的 ergosterol 含量或结构的变化有关.
- 新兴的耐药性需要对药物和真菌相互作用有更深入的了解.
结论:
- 在Candida的抗真菌药物耐药性构成了重大的临床挑战.
- 了解抗药性机制,特别是安二乙的抗药性机制,对于开发有效的治疗策略至关重要.
- 需要继续进行研究,以应对侵袭性真菌感染日益严重的威胁.
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