草药-华法林相互作用的安全问题
Subhajit Hazra1, Preet Amol Singh1, Neha Bajwa1
1University Institute of Pharma Sciences (UIPS), Chandigarh University, Mohali-140413, Punjab, India.
Current drug metabolism
|March 11, 2024
概括
草药和华法林的相互作用带来了严重的安全风险,导致严重的出血和血栓形成. 了解这些草药-华法林相互作用 (HWI) 对患者安全和明智的医疗保健决策至关重要.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 草药相互作用 草药相互作用
- 药品安全 药品安全
背景情况:
- 华法林是一种广泛使用的抗凝剂,但其安全性因与草药相互作用而受到损害.
- 许多研究表明,当华法林与草药产品或配方一起服用时,会出现严重的不良事件.
研究的目的:
- 审查草药-华法林相互作用 (HWI) 的机制.
- 强调药理动力学-药理动力学 (PKPD) 相互作用和各种消费场景中的HWI证据.
- 为了整合关于草药-华法林相互作用的信息.
主要方法:
- 使用各种科学数据库进行了有针对性的文献审查.
- 系统地获取了关于草药与华法林相互作用 (HWI) 的信息.
- 专注于PKPD相互作用和来自不同消费场景的证据.
主要成果:
- HWI的致命后果包括出血,血栓形成,脑下关节下出血和腹腔内血瘤.
- 特定的草药,如*穿孔*, *生 officinale*, *疫苗 oxycoccos*, *花天堂*和*花花*都涉及.
- 草药如 *Coptis chinensis* 和 *Phellodendron amurense* 在血蛋白结合方面竞争,增加自由华法林及其抗血作用.
- 美国海 (梨) 的消费可以降低国际标准化比率 (INR) 的水平.
结论:
- 迫切需要更新草药-华法林相互作用数据库.
- 教育患者和医疗保健提供者对HWI至关重要.
- 采用自然语言处理等技术可以帮助医疗保健专业人员做出明智的决定,防止HWI.
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