里瓦斯蒂格明用于抗胆固醇的管理
Angela L Chiew1,2, Amanda G Holford3,4, Betty S H Chan1,2
1Department of Clinical Toxicology, Prince of Wales Hospital, Randwick, Australia.
Clinical toxicology (Philadelphia, Pa.)
|March 11, 2024
概括
里瓦斯蒂格明有效地治疗抗胆固醇迷,当肉斯蒂格明是不可用的. 口服里瓦斯蒂格明在控制抗胆毒性毒性症状方面,比通过皮肤贴片更有效.
科学领域:
- 毒理学 毒理学 毒理学
- 紧急医疗 紧急医疗
- 药理学 药理学是指药理学的学科.
背景情况:
- 过量服用抗胆固醇药物经常导致妄,从轻微的兴奋到严重的行为障碍.
- 菲索斯蒂格是抗胆固醇的有效解药,但面临着有限的可用性.
- 利瓦斯蒂格明是一种随时可用的替代品,越来越多地用于抗胆固醇迷,但对其疗效的研究很少.
研究的目的:
- 为了评估里瓦斯蒂格明在治疗抗胆性痴呆症方面的有效性.
- 为了比较口服与透皮利瓦斯蒂格明配方的疗效.
- 评估在里瓦斯蒂格明注射后需要额外的肠外治疗的需要.
主要方法:
- 一项对50名因抗胆固醇狂妄症而接受口服或通过皮肤给予利瓦斯蒂格明治疗的患者的回顾性审查.
- 从2019年1月到2023年6月收集的数据来自两个毒理学部门.
- 主要结局:需要进一步的腹腔内治疗 (镇静剂或生胺).
主要成果:
- 口服里瓦斯蒂格明 (6毫克) 与通过皮肤给予的里瓦斯蒂格明 (9.5毫克/24小时补丁) 相比,与进一步亲肠治疗的需求显著降低 (32%对73%,P=0.010).
- 常见的抗胆固醇毒性症状包括动脉动脉 (88%) 和尿路保留 (80%).
- 没有任何不良事件,如白心脏或胃肠道症状被报告后rivastigmine;一个发作发生后physostigmine.
结论:
- 里瓦斯蒂格明可以作为抗胆固醇的可行的治疗选择,特别是当肉斯蒂格明无法获得时.
- 口服里瓦斯蒂格明似乎比皮肤贴片更有效,可能是由于更快的开始或足够的剂量.
- 需要进一步的研究来优化对抗胆固醇狂妄症管理的利瓦斯蒂格胺剂量和管理.
相关概念视频
01:22Alzheimer's Disease: Treatment
188
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
188
01:30Indirect-Acting Cholinergic Agonists: Pharmacological Actions
673
Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
673
01:26Anticholinesterase Agents: Poisoning and Treatment
856
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
856
01:26Cholinergic Antagonists: Therapeutic Uses
747
Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
747
01:24Parkinson's Disease: Treatment
268
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
268
01:11Direct-Acting Cholinergic Agonists: Therapeutic Uses
740
Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren...
740