从2010年到2021年,美国中毒中心向美国中毒中心报告了fomepizole的使用情况
James B Leonard1, Faisal S Minhaj2, Kennedy Erickson3
1Maryland Poison Center, Department of Practice, Sciences, and Health Outcomes Research, University of Maryland School of Pharmacy, Baltimore, MD, USA.
由于诊断方面的挑战,福梅皮佐尔经常在有毒酒精中毒时经验上给予. 最近的数据显示,对非有毒酒精暴露的使用增加,强调需要更好的诊断测试.
科学领域:
- 毒理学和紧急医疗医学
- 临床药理学 临床药理学
- 公共卫生监督 公共卫生监督
背景情况:
- 毒性酒精中毒的诊断依赖于临床症状和非特异性实验室测试,由于可用性有限.
- 福梅皮佐尔是标准的解毒剂,在确诊之前经常经验性地使用.
- 这项研究研究了模仿有毒酒精的物质,并比较了福梅皮佐尔治疗患者的临床因素.
研究的目的:
- 为了识别使用福梅皮治疗的无毒酒精暴露.
- 为了比较受福梅皮佐尔治疗的有毒和无毒酒精暴露之间的临床特征.
- 评估经验性使用福梅皮对医疗保健成本和诊断实践的影响.
主要方法:
- 国家毒素数据系统 (2010-2021) 的回顾性分析.
- 纳入标准:使用福梅皮佐尔.
- 排除标准:2020-2021年对帕拉西他 (乙氨基) 的暴露.
主要成果:
- 福梅皮佐尔被注射了25,110次;使用量每年增加.
- 非毒性酒精暴露 (乙醇,未知药物) 从2020年开始,福梅皮的使用量增加.
- 毒性酒精暴露者比非毒性暴露者更老,更男性,并且不太可能有严重的代谢障碍.
结论:
- 经验性使用fomepizole是常见的,通常用于非有毒的酒精摄入,由于诊断困难.
- 这种做法带来了相当大的成本 (每年150万美元至250万美元).
- 改进对有毒酒精的实验室检测可以提高诊断准确度并优化福梅皮的利用率.
更多相关视频
05:20Avocado Sample Preparation Using the QuEChERS Method with Ammonium Formate for Pesticide Analysis
Published on: December 8, 2023
16:02Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
相关概念视频
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Prevention of Further Absorption of Poison
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Drug Regulation
Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
