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相关概念视频

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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使用从磁化准备的快速梯度回声的定量敏感度映射量化脑微血流量化.

Nashwan Naji1, Myrlene Gee2, Glen C Jickling2

  • 1Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.

NMR in biomedicine
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概括
此摘要是机器生成的。

通过磁化准备的快速梯度回声定量敏感度映射 (MPRAGE-QSM) 可以在脑成像中检测微型血流. 这种方法为3特斯拉及以上的标准技术提供了可比的灵敏度,没有额外的时间成本.

关键词:
3 T T T 3 T T T T T 在线阅读这就是MPRAGE.在QSM中,QSM是QSM.微型出血体的微型出血体

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科学领域:

  • 神经成像是一种神经成像.
  • 医学物理 医学物理
  • 放射学 放射学是一门学科.

背景情况:

  • T1加权磁化准备的快速梯度回声 (MPRAGE) 是大脑结构成像的标准.
  • MPRAGE相位图像提供了通过定量敏感度映射 (QSM) 进行微血层评估的潜力.
  • 微血是各种神经疾病中的关键标志物.

研究的目的:

  • 评估基于MPRAGE的QSM在评估微型血液负担方面的潜力.
  • 为了比较MPRAGE-QSM的检测灵敏度和精度与标准的多回声梯度回声QSM (MEGE-QSM).
  • 探索影响MPRAGE-QSM图像质量和检测性能的因素.

主要方法:

  • 在体内对15个受试者的108个微型血液的QSM分析,使用3-T MPRAGE和MEGE序列.
  • 模拟以评估MPRAGE-QSM在不同磁场强度 (1.5T,3T,7T) 的灵敏度,回声时间和微出血的特征 (大小,易感性,位置).
  • 在MPRAGE-QSM和MEGE-QSM之间比较微型血层的大小,平均敏感度和总敏感度估计.

主要成果:

  • 在体内,MPRAGE-QSM检测到微型血液,其灵敏度与MEGE-QSM相似,尽管它们看起来更小,平均灵敏度更高.
  • 来自MPRAGE-QSM的总敏感性估计与MEGE-QSM密切一致 (斜率:0.97,r2:0.94).
  • 模拟显示MPRAGE-QSM检测灵敏度在3T和7T与1.5T相比显著改善,检测率分别为0.80和0.88对于至少1个声素直径和0.4ppm灵敏度的微型血液.

结论:

  • MPRAGE-QSM是一种可行的方法,可以在3T或更高的磁场下检测和量化微型血流 (≥1伏克尔),而无需额外的扫描时间.
  • 总灵敏度测量对序列变化更具稳定性,可能使不同成像协议之间的数据协调成为可能.
  • 当标准T2*加权图像无法获得或缺乏足够的空间分辨率来检测微型血流时,MPRAGE-QSM特别有价值.