长期COVID患者的高磁血和25-氧维生素D缺乏症
Fernando Guerrero-Romero1, Claudia I Gamboa-Gómez1, Martha Rodríguez-Morán1
1Biomedical Research Unit, Mexican Social Security Institute, Durango, Dgo, México.
Magnesium research
|March 11, 2024
概括
长期COVID患者经常经历低磁血和维生素D缺乏,这与更严重的临床症状相关. 解决这些缺陷可能有助于管理长期的COVID表现.
科学领域:
- 生物化学 生物化学
- 临床医学 临床医学
- 公共卫生 公共卫生
背景情况:
- 长期COVID是2019年冠状病毒疾病的延长过程,呈现出各种不同的临床表现.
- 长期COVID患者中经常观察到高磁血和维生素D缺乏症.
- 这些缺陷与患者经历的各种神经和身体症状有关.
研究的目的:
- 调查长期COVID患者中低磁血症和25-氧维生素D缺乏症的患病率.
- 评估这些缺陷与长期COVID中的临床表现数量之间的关联.
主要方法:
- 一项涉及125名被诊断患有长期COVID的成年人的横截面研究.
- 参与者被分为一个风险组 (低血症和/或维生素D缺乏症) 和一个对照组.
- 血清水平≤1.8 mg/dL和25-基维生素D水平<30 ng/mL定义的缺乏.
主要成果:
- 与对照组相比,风险组的长期COVID临床症状数量显著增加.
- 疲劳,记忆丧失,注意力缺陷,关节疼痛,焦虑,睡眠障碍,肌痛和抑郁症在风险组中很常见.
- 调整后的赔率比为3.1 (95%CI为2.3-12.4,p=0.005),表明在长期COVID中,低磁血和维生素D缺乏之间存在显著的关联.
结论:
- 长期COVID患者经常缺乏和25-氧维生素D.
- 这些缺陷与长期COVID相关的临床表现数量增加有关.
- 对补充剂的进一步研究可能是有必要的,以减轻长期COVID症状.
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