治疗视通路质瘤的儿科患者的非常长期结果:一个纵向队列研究
Alice Morin1, Rodrigue Allodji2,3,4, Dulanjalee Kariyawasam5
1Department of Children and Adolescents Oncology, Gustave Roussy, Paris-Saclay University, Villejuif, France.
Neuro-oncology
|March 11, 2024
概括
儿童视觉通路质瘤 (OPG) 幸存者面临着晚期复发,第二次癌症和严重健康问题的高风险,包括视力障碍和垂体缺陷. 长期跟踪对于管理这些晚期并发症和改善生活质量至关重要.
科学领域:
- 儿科瘤学 儿科瘤学
- 神经瘤学神经瘤学
- 癌症的生存率 癌症的生存率
背景情况:
- 光路结质瘤 (OPG) 是儿童大脑瘤的重要原因,占病例的5%.
- 复发性OPG需要多次治疗,增加了儿童癌症幸存者的长期并发症风险.
研究的目的:
- 评估童年光通路质瘤幸存者的长期结果和晚期健康状况.
- 为了确定与这种患者群体的死亡率和发病率相关的风险因素.
主要方法:
- 分析了182名在18岁之前被诊断患有OPG的患者,诊断后至少存活了5年.
- 数据收集包括医疗记录,长期随访和国家死亡记录.
- 随访时间中位数为17.2年,评估了生存率,晚期事件和健康状况.
主要成果:
- 20年条件整体存活率为79.9%. 晚期事件包括82次复发,9次恶性瘤和15例死亡.
- 死亡的重大风险因素包括神经纤维素炎1型 (NF1) 患者的放射治疗暴露和下丘脑参与.
- 95%的幸存者患有健康状况,特别是视力障碍,垂体缺陷和神经认知缺陷. 在21名患者中观察到脑血管事件.
结论:
- 晚期复发,二次恶性瘤和脑血管疾病是关键的晚期事件,有助于OPG幸存者的过早死亡.
- 高发病率需要全面的癌症后护理,以提高幸存者的生活质量.
- 识别特定的风险因素可以帮助分层患者,以量身定制的长期随访方案.
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