升高的XI因子与不知来源的复发性左心室血栓有关
Łukasz Zandecki1, Michał Ząbczyk2,3, Anetta Undas2,3
1Institute of Medical Sciences, Jan Kochanowski University, Kielce, Poland.
European journal of clinical investigation
|March 11, 2024
概括
升高的XI因子 (FXI) 水平与左心室血栓 (LVT) 的形成和复发有关. 较高的FXI表明前血栓状况,可能识别可能从向治疗中受益的患者.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 血栓形成研究研究
背景情况:
- 升高的XI因子 (FXI) 是已知的血栓栓塞的风险因素.
- FXI水平与左心室血栓 (LVT) 形成,复发和随后的血栓栓塞事件之间的关联需要进一步调查.
研究的目的:
- 调查FXI水平与LVT存在之间的关联.
- 为了确定FXI水平是否与未知来源的LVT患者的LVT复发和随后的血栓栓塞事件相关.
主要方法:
- 一项病例控制研究,涉及54名先前接受过LVT的患者和54名对照患者.
- 测量FXI水平,血凝块透性 (Ks),纤维解质时间 (CLT),内源性血栓潜力 (ETP),·维勒布兰德因子 (vWF) 和纤维解质蛋白.
- 对LVT复发,缺血性中风或全身栓塞的后续评估.
主要成果:
- 较高的FXI水平 (>120%) 在LVT患者 (25.9%) 与对照组 (11.1%) 相比更为普遍,特别是活跃的FXI患者.
- 与年龄相关的FXI水平,Ks和CLT,但不是ETP,vWF或纤维解蛋白.
- 在随访期间,主要终点发生在31.5%的LVT患者中,而对照组为7.4%,FXI升高与主要终点 (OR1.18) 独立相关.
结论:
- 升高的FXI,与前血栓状况相结合,特征为先前未知来源的LVT患者.
- 高的FXI水平会导致LVT复发和/或缺血性中风.
- 测量FXI可能有助于识别可能从延长抗凝剂或FXI抑制剂中受益的患者.
相关概念视频
Anticoagulant Drugs: Low-Molecular-Weight Heparins
696
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
696
Extrinsic and Intrinsic Pathways of Hemostasis
7.6K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
7.6K
Disorders of Hemostasis
904
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
904
Clot Retraction and Fibrinolysis
5.9K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
5.9K


