全因和因特定死亡率按螺旋计图案和性别 - - 一项基于人口的队列研究
Helena Backman1, Sami Sawalha2, Ulf Nilsson2
1Section of Sustainable Health/The OLIN Unit, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Therapeutic advances in respiratory disease
|March 11, 2024
概括
患有慢性呼吸道阻塞 (CAO) 和限制性螺旋测量模式 (RSP) 的男性面临更高的死亡风险. CAO与女性的呼吸道死亡和男性的心血管死亡有关,而RSP与两性呼吸道死亡有关.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 心血管健康 心血管健康
背景情况:
- 慢性呼吸道阻塞 (CAO) 和限制性螺旋测量模式 (RSP) 是已知的死亡风险因素.
- 然而,对于这些疾病的所有原因和特定原因死亡率的性别差异仍然被低估.
研究的目的:
- 调查所有原因和特定原因死亡率的性别依赖变化,在患有CAO和RSP的个体中.
- 将这些模式与正常肺功能 (NLF) 个体中观察到的模式进行比较.
主要方法:
- 一项基于人口的前性队列研究使用了来自北瑞典阻塞性肺病 (OLIN) 研究 (2002-2004) 的数据.
- 死亡率数据收集到2016年4月,涵盖了大约19,000个患者年.
- 考克斯和细灰回归模型被用来估计调整的危险比率,控制年龄,BMI,性别和吸烟状况.
主要成果:
- 与NLF相比,CAO和RSP都与更高的调整风险有关,这些风险主要由男性驱动.
- CAO显示呼吸道和心血管死亡的风险增加. 呼吸道死亡风险在女性中显著,而心血管死亡风险在男性中显著.
- 在两性中,RSP与呼吸道死亡的风险增加有关,但与心血管死亡无关.
结论:
- 在CAO和RSP中全因死亡率的风险增加主要在男性中观察到.
- CAO与不同的特定原因死亡模式有关:女性的呼吸道死亡和男性的心血管死亡.
- RSP与增加呼吸道死亡风险有关,同样影响两性.
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