艾滋病毒感染者和未感染者的mopox临床特征和结果:一项全国性比较研究
Isaac Núñez1,2, Santa E Ceballos-Liceaga3, Alethse de la Torre4
1Department of Medical Education, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga #15, Belisario Domínguez Sección XVI, Tlalpan, Mexico City, Mexico, 14080. Email: isaac.nunezs@incmnsz.mx. Phone: 5554870900.
Journal of acquired immune deficiency syndromes (1999)
|March 11, 2024
概括
艾滋病毒感染者 (PLWH) 面临严重感染和死亡的风险明显更高. 这项研究强调了针对这一弱势群体的有针对性的mpox预防和治疗策略的迫切需要.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 马普克斯不成比例地影响着艾滋病毒感染者 (PLWH).
- 关于PLWH和没有艾滋病毒的人之间的mopox严重性的比较数据有限.
- 这项研究解决了对墨西哥mopox临床过程的比较数据的需求.
研究的目的:
- 为了比较墨西哥艾滋病毒感染者和没有艾滋病毒感染者的mpox临床特征和结果.
- 确定与PLWH中严重的mopox和死亡率相关的风险因素.
- 为预防和管理mopox的公共卫生战略提供信息.
主要方法:
- 在墨西哥进行的全国性观察性研究 (2022年5月至11月).
- 包括3291个被证实为mopox.的个人.
- 使用多变量逻辑回归比较临床和社会人口统计特征.
主要成果:
- 59%的mopox病例发生在PLWH中.
- 患有PLWH的人患重型POPOX的风险增加了2.6倍,死亡风险增加了10.8倍.
- 在PLWH中,耳痛,直肠炎和尿路炎的发病率较高.
结论:
- 携带艾滋病毒的人患重症mpox和死亡风险要高得多.
- 这些发现强调了针对PLWH量身定制的mopox干预措施的急需.
- 公共卫生工作应优先考虑mopox疫苗接种和HIV阳性个体的早期治疗.
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