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离子液体介导的乙体用于通过皮肤输送胰岛素

Fahmida Habib Nabila¹, Rashedul Islam¹, Islam Md Shimul²

¹Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. m-goto@mail.cstm.kyushu-u.ac.jp.

Chemical communications (Cambridge, England)

|March 11, 2024

概括

使用1,2-二米里斯托尔-sn-glycero-3-phosphatidylcholine (DMPC) 离子液和乙醇的新型以索姆 (ET) 配方增强了通过皮肤递送胰岛素. 这些先进的ET显示出更好的稳定性,封装性和皮肤透性,以有效的药物输送.

科学领域:

制药科学制药科学
药物输送系统药物输送系统
纳米技术纳米技术

背景情况:

像胰岛素这样的高分子量药物通过皮肤传递面临着挑战.
传统的以体 (ET) 配方在稳定性和有效性方面存在局限性.
离子液体为新型药物输送系统提供了潜力.

研究的目的:

开发和评估用于增强通过皮肤输送胰岛素的新型以太体 (ET) 配方.
调查基于1,2-二米里斯托尔-sn-甘油-3-酸丁 (DMPC) 的离子液和乙醇度对ET特性的影响.
评估胰岛素装载ET的稳定性,封装效率和皮肤透性.

主要方法:

使用基于DMPC的离子液体和不同度的乙醇配制以体 (ETs).
在ET囊泡中封装胰岛素.
对ET囊泡大小,稳定性和药物封装效率的评估.
在体外评估ET配方胰岛素的皮肤透率.

主要成果:

与传统的DMPCET相比,胰岛素载入的ET囊泡显示出长期稳定性.
新型ET配方表现出明显更高的胰岛素封装效率.
在开发的ET时,观察到胰岛素的皮肤透能力增加.
乙醇度被优化以改善配方特性.

结论:

基于DMPC的离子液体乙体为通过皮肤输送胰岛素提供了一个有前途的平台.
这些新的ET配方克服了传统系统的局限性,提高了稳定性和药物透性.
这些发现支持这种方法在非侵入性胰岛素治疗中的潜力.

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