系统性硬化症中的眼部参与:关于微血管损伤的最新审查和新见解
Matteo Mario Carlà1,2, Gloria Gambini1,2, Tomaso Caporossi2,3
1Ophthalmology Department, "Fondazione Policlinico Universitario A. Gemelli, IRCCS", Rome, Italy.
Ocular immunology and inflammation
|March 11, 2024
概括
系统性硬化症 (SSc) 涉及眼部微血管病变,可通过光学连贯性断层扫描血管学 (OCTA) 检测. 这种血管功能障碍有助于早期SSc识别和疾病分期.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 系统性硬化症 (SSc) 是一种复杂的多系统性疾病,具有免疫,血管和纤维的组成部分.
- 雷诺现象和指甲折视频毛囊镜 (NVC) 异常是SSc的早期指标,通常在系统性硬化症 (VEDOSS) 的早期疾病中见到.
- 在SSc的眼部表现是常见的和多样化的,包括干眼,眼异常和潜在的玻璃眼,源于复杂的病理生理机制.
研究的目的:
- 调查眼部微血管病在系统性硬化症 (SSc) 早期检测和分期中的作用.
- 评估光学连贯断层扫描血管学 (OCTA) 在评估SSc相关的眼血管变化的实用性.
主要方法:
- 对SSc眼部参与现有文献的审查,包括早期诊断方法,如视网膜学和光素血管学.
- 专注于光连贯断层扫描血管学 (OCTA) 的进展,用于视网膜和胆道血管的高分辨率成像.
- 眼血管发现与临床SSc特征,NVC和疾病阶段的相关性.
主要成果:
- 眼部症状,如眼睛干燥和眼异常影响大量的SSc患者.
- 视网膜学和血管学之前显示了~50%的SSc患者的血管疾病.
- OCTA揭示了胆囊和视网膜血管的显著损伤,与NVC和皮肤疾病相关,即使在早期的SSc阶段 (VEDOSS).
结论:
- 眼睛微血管病变,特别是OCTA可视化的眼睛微血管病变,是SSc.的一个敏感指标.
- OCTA的发现与系统性疾病标志物相关,可以帮助区分SSc阶段.
- 眼部微血管病变显示为早期SSc识别的非侵入性工具的承诺.
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