与阿尔茨海默病病理,神经炎症和大脑结构相关的终身压力事件在风险丰富的队列中
Eleni Palpatzis1,2,3, Muge Akinci1,2,3, Pablo Aguilar-Dominguez1,2
1Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
Annals of neurology
|March 11, 2024
概括
累积的压力生活事件 (SLE) 与阿尔茨海默病 (AD) 病理学没有直接联系. 然而,童年和中年期间的SLE,特别是在有精神病史或特定性别的个体中,与AD生物标志物和大脑变化有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 老年学是一门学科.
背景情况:
- 慢性压力越来越多地与阿尔茨海默氏症 (AD) 病原发生有关,影响大脑结构和炎症.
- 调查累积压力生活事件 (SLEs) 的影响对于了解AD风险因素至关重要.
研究的目的:
- 检查累积压力生活事件 (SLEs) 与阿尔茨海默病 (AD) 病理,神经炎症和灰质 (GM) 之间的关联.
- 为了探索这些协会在认知无障碍 (CU) 个体对AD的风险增加.
主要方法:
- 来自ALFA队列的1,290名CU参与者 (48-77岁) 的横截面队列研究.
- 对脑脊液 (CSF) 生物标志物的分析 (酸化,Aβ比),IL-6,以及对GM体积的结构性MRI.
- 多重回归分析,分层和相互作用分析,考虑性别和精神病史.
主要成果:
- 童年和中年期的SLE,而不是总的SLE,与AD病理生理学和神经炎症有关.
- 患有精神病史的个人显示了SLEs和更高的p-tau181和IL-6之间的关联.
- 观察到的性别特异性差异:有精神病史和较高SLEs的男性有较低的Aβ1-42/1-40;有精神病史的女性显示GM体积减少.
结论:
- 总累积的压力生活事件 (SLEs) 与阿尔茨海默病 (AD) 生物标志物或大脑缩没有直接关联.
- SLEs对AD相关途径的影响取决于生命周期 (早期/中年),性别和精神病史.
- 研究结果强调了压力时间和个人因素在AD病变发生过程中的细微作用.
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